Methylation of Hepatitis B Virus DNA and Liver-specific Suppression of RNA Production in Transgenic Mouse

Ken Ichi Yamamura, Toshiki Tsurimoto, Taeko Ebihara, Kouzin Kamino, Asao Fujiyama, Takahiro Ochiya, Kenichi Matsubara

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Three lines of transgenic mice carrying hepatitis B virus (HBV) DNA were produced. In a pSHBIBB transgenic mouse carrying one copy of BamHl fragment of HBV with a deletion of BgHl-BgtLI fragment, no RNA transcription was observed. Transgenic mice that had integrated either one or three tandem copies of HBV DNA produced RNA in various tissues except liver. However, neither initiation nor termination of transcription occurred at the correct place. Hepatitis B surface antigen and hepatitis B e antigen were not detectable in these transgenic mice. HBV DNA was methylated at all CCGG sequences, which might have resulted in aberrant RNA production. In two out of five transgenic mice HBV DNA was integrated into the Y chromosome. Although the frequency is unusually high, the mechanism is not known yet.

元の言語英語
ページ(範囲)681-688
ページ数8
ジャーナルJapanese Journal of Cancer Research GANN
78
発行部数7
出版物ステータス出版済み - 1 1 1987
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Yamamura, K. I., Tsurimoto, T., Ebihara, T., Kamino, K., Fujiyama, A., Ochiya, T., & Matsubara, K. (1987). Methylation of Hepatitis B Virus DNA and Liver-specific Suppression of RNA Production in Transgenic Mouse. Japanese Journal of Cancer Research GANN, 78(7), 681-688.