Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas

Tomomi Marugame, Emiko Tsuji, Hisako Inoue, Sachiko Shinomiya, Chikako Kiyohara, Kazuya Onuma, Hiroaki Hamada, Hiroko Koga, Koichi Handa, Hitomi Hayabuchi, Suminori Kono

研究成果: Contribution to journalArticle査読

50 被引用数 (Scopus)

抄録

A homozygous mutation at bp 677 in the gene for the methylenetetrahydrofolate reductase (MTHFR) was previously shown to be associated with a decreased risk of colorectal cancer. We examined the relation between the MTHFR genetic polymorphism and risk of colorectal adenoma in Japanese men using 205 cases of colorectal adenomas and 220 controls of normal total colonoscopy. The homozygous mutation was not measurably associated with colorectal adenomas. The findings corroborate the lack of an association between the MTHFR genotype and colorectal adenomas, but do not deny the possibility that the genotype may be involved in the late stage of colorectal carcinogenesis. Copyright (C) 2000 Elsevier Science Ireland Ltd.

本文言語英語
ページ(範囲)181-186
ページ数6
ジャーナルCancer Letters
151
2
DOI
出版ステータス出版済み - 4 14 2000

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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