抄録
To survive in harsh environments, phyllosphere microorganisms have developed numerous adaptive strategies against stressors. One such strategy is the synthesis of compounds that absorb ultraviolet A radiation (UVA). The chemical structure of a UVA-absorbing compound from Methylobacterium sp. strain W-213 was elucidated by spectroscopic analyses. 1H, 13C, and two-dimensional nuclear magnetic resonance spectra indicated the presence of N-methyl-α-galactosamine. The entire structure was revealed by interpretation of INADEQUATE and high-resolution liquid chromatography/electrospray ionization mass spectra. The absolute configuration was established by X-ray analysis and the compound was identified as 2-((4aR,6R,7R,8R,8aR)-7,8-dihydroxy-6-hydroxymethyl-1,2-dimethyl-4aH,6H,7H,8H,8aH-pyrano[2,3-b][1,4]oxazin-3-yl)-2-iminoacetic acid and named ‘methylobamine’. Methylobamine shows promise for pharmaceutical and cosmetic applications due to its high polarity, UVA absorption properties, and stability under UVA exposure.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 141-143 |
| ページ数 | 3 |
| ジャーナル | Natural Product Communications |
| 巻 | 13 |
| 発行部数 | 2 |
| 出版物ステータス | 出版済み - 1 1 2018 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Drug Discovery
- Plant Science
- Complementary and alternative medicine
これを引用
Methylobamine, a UVA-absorbing compound from the plant-associated bacteria methylobacterium sp. / Kamo, Tsunashi; Hiradate, Syuntaro; Suzuki, Ken; Fujita, Ichiro; Yamaki, Shinji; Yoneda, Tadashi; Koitabashi, Motoo; Yoshida, Shigenobu.
：: Natural Product Communications, 巻 13, 番号 2, 01.01.2018, p. 141-143.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Methylobamine, a UVA-absorbing compound from the plant-associated bacteria methylobacterium sp.
AU - Kamo, Tsunashi
AU - Hiradate, Syuntaro
AU - Suzuki, Ken
AU - Fujita, Ichiro
AU - Yamaki, Shinji
AU - Yoneda, Tadashi
AU - Koitabashi, Motoo
AU - Yoshida, Shigenobu
PY - 2018/1/1
Y1 - 2018/1/1
N2 - To survive in harsh environments, phyllosphere microorganisms have developed numerous adaptive strategies against stressors. One such strategy is the synthesis of compounds that absorb ultraviolet A radiation (UVA). The chemical structure of a UVA-absorbing compound from Methylobacterium sp. strain W-213 was elucidated by spectroscopic analyses. 1H, 13C, and two-dimensional nuclear magnetic resonance spectra indicated the presence of N-methyl-α-galactosamine. The entire structure was revealed by interpretation of INADEQUATE and high-resolution liquid chromatography/electrospray ionization mass spectra. The absolute configuration was established by X-ray analysis and the compound was identified as 2-((4aR,6R,7R,8R,8aR)-7,8-dihydroxy-6-hydroxymethyl-1,2-dimethyl-4aH,6H,7H,8H,8aH-pyrano[2,3-b][1,4]oxazin-3-yl)-2-iminoacetic acid and named ‘methylobamine’. Methylobamine shows promise for pharmaceutical and cosmetic applications due to its high polarity, UVA absorption properties, and stability under UVA exposure.
AB - To survive in harsh environments, phyllosphere microorganisms have developed numerous adaptive strategies against stressors. One such strategy is the synthesis of compounds that absorb ultraviolet A radiation (UVA). The chemical structure of a UVA-absorbing compound from Methylobacterium sp. strain W-213 was elucidated by spectroscopic analyses. 1H, 13C, and two-dimensional nuclear magnetic resonance spectra indicated the presence of N-methyl-α-galactosamine. The entire structure was revealed by interpretation of INADEQUATE and high-resolution liquid chromatography/electrospray ionization mass spectra. The absolute configuration was established by X-ray analysis and the compound was identified as 2-((4aR,6R,7R,8R,8aR)-7,8-dihydroxy-6-hydroxymethyl-1,2-dimethyl-4aH,6H,7H,8H,8aH-pyrano[2,3-b][1,4]oxazin-3-yl)-2-iminoacetic acid and named ‘methylobamine’. Methylobamine shows promise for pharmaceutical and cosmetic applications due to its high polarity, UVA absorption properties, and stability under UVA exposure.
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UR - http://www.scopus.com/inward/citedby.url?scp=85048357542&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85048357542
VL - 13
SP - 141
EP - 143
JO - Natural Product Communications
JF - Natural Product Communications
SN - 1934-578X
IS - 2
ER -