Mexiletine reverses Oxaliplatin-Induced neuropathic pain in rats

Nobuaki Egashira, Shingo Hirakawa, Takehiro Kawashiri, Takahisa Yano, Hiroaki Ikesue, Ryozo Oishi

研究成果: Contribution to journalArticle査読

38 被引用数 (Scopus)

抄録

Oxaliplatin is a platinum-based chemotherapy drug characterized by the development of acute and chronic peripheral neuropathies. Mexiletine, an orally available Na+-channel blocker, has widely been used in patients with chronic painful diabetic neuropathy. In the present study, we examined the effect of mexiletine on oxaliplatin-induced neuropathic pain in rats. Mexiletine (100, but not 10 and 30, mg/kg, p.o.) completely reversed both mechanical allodynia and cold hyperalgesia induced by oxaliplatin (4 mg/kg, i.p., twice a week). Lidocaine (30, but not 3 and 10, mg/kg, i.p.) also significantly relieved both pain behaviors. These results suggest that mexiletine may be effective in relieving the oxaliplatin-induced neuropathic pain clinically.

本文言語英語
ページ(範囲)473-476
ページ数4
ジャーナルJournal of Pharmacological Sciences
112
4
DOI
出版ステータス出版済み - 4 16 2010

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学

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