Micelles consisting of choline phosphate-bearing Calix[4]arene lipids

Shota Fujii, Koichi Nishina, Shimpei Yamada, Shinichi Mochizuki, Noboru Ohta, Atsushi Takahara, Kazuo Sakurai

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

抄録

We synthesized new calix[4]arene-based lipids, denoted by CPCaLn, bearing the choline phosphate (CP) group which is an inverse phosphoryl choline (PC) structure. Small-angle X-ray scattering and multi-angle light scattering coupled with field flow fractionation showed that these lipids form monodisperse micelles with a fixed aggregation number and diameters of 1.9 and 2.6 nm for lipids bearing C3 and C6 alkyl tails, respectively. Furthermore, when CPCaLn was mixed with the fluorescein isothiocyanate (FITC)-bearing lipids and added to cells, strong fluorescence was observed at 37 °C, but not at 4°C, indicating that the micelles were taken up by the cells through endocytosis. Recent studies have shown that replacement of polymer-attached PC groups with CP groups markedly promotes cellular uptake, even though the surface charge is neutral. On the basis of the idea, CPCaLn micelles interacted with cells in the same way, suggesting that the micelles bearing CP groups are expected to use as carriers in the drug delivery system. This journal is

元の言語英語
ページ(範囲)8216-8223
ページ数8
ジャーナルSoft Matter
10
発行部数41
DOI
出版物ステータス出版済み - 11 7 2014

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Bearings (structural)
choline
Phosphorylcholine
Micelles
lipids
micelles
phosphates
Lipids
Choline
cells
Surface charge
Fractionation
Fluorescein
X ray scattering
Light scattering
Flow fields
Polymers
Agglomeration
fractionation
Fluorescence

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

これを引用

Fujii, S., Nishina, K., Yamada, S., Mochizuki, S., Ohta, N., Takahara, A., & Sakurai, K. (2014). Micelles consisting of choline phosphate-bearing Calix[4]arene lipids. Soft Matter, 10(41), 8216-8223. https://doi.org/10.1039/c4sm01355g

Micelles consisting of choline phosphate-bearing Calix[4]arene lipids. / Fujii, Shota; Nishina, Koichi; Yamada, Shimpei; Mochizuki, Shinichi; Ohta, Noboru; Takahara, Atsushi; Sakurai, Kazuo.

:: Soft Matter, 巻 10, 番号 41, 07.11.2014, p. 8216-8223.

研究成果: ジャーナルへの寄稿記事

Fujii, S, Nishina, K, Yamada, S, Mochizuki, S, Ohta, N, Takahara, A & Sakurai, K 2014, 'Micelles consisting of choline phosphate-bearing Calix[4]arene lipids', Soft Matter, 巻. 10, 番号 41, pp. 8216-8223. https://doi.org/10.1039/c4sm01355g
Fujii S, Nishina K, Yamada S, Mochizuki S, Ohta N, Takahara A その他. Micelles consisting of choline phosphate-bearing Calix[4]arene lipids. Soft Matter. 2014 11 7;10(41):8216-8223. https://doi.org/10.1039/c4sm01355g
Fujii, Shota ; Nishina, Koichi ; Yamada, Shimpei ; Mochizuki, Shinichi ; Ohta, Noboru ; Takahara, Atsushi ; Sakurai, Kazuo. / Micelles consisting of choline phosphate-bearing Calix[4]arene lipids. :: Soft Matter. 2014 ; 巻 10, 番号 41. pp. 8216-8223.
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