Micro-LED Array-Based Photo-Stimulation Devices for Optogenetics in Rat and Macaque Monkey Brains

Yasumi Ohta, Mark Christian Guinto, Takashi Tokuda, Mamiko Kawahara, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Kiyotaka Sasagawa, Hirotaka Onoe, Reona Yamaguchi, Yoshinori Koshimizu, Kaoru Isa, Tadashi Isa, Kenta Kobayashi, Yasemin M. Akay, Metin Akay, Jun Ohta

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)


Optogenetics is a powerful tool for controlling biological functions using light. Optical fibers have been extensively utilized in optical stimulation devices for optogenetics. However, the use of optical fibers results in a small photo-stimulation region. In this study, micro-LED array devices were developed to achieve large-area photo-stimulation in the brain of a large animal, such as macaque monkeys. Planar and linear micro-LED array devices were designed and fabricated to photo-stimulate the prefrontal cortex (PFC) and ventral tegmental area (VTA) of the brain and induce a neurochemical response. Device operation, optical intensity, and safety were first characterized using rats. Subsequently, the devices were used to photo-stimulate the brain of macaque monkeys. In addition, microdialysis in the PFC was performed. The devices detected modulated levels of dopamine in the brains. Thus, the photo-stimulation of both the PFC and VTA were successfully achieved, and the effectiveness of the developed micro-LED array devices was demonstrated. The study will help facilitate further studies on micro-LED array stimulation for system-wide optogenetic manipulation in large animals.

ジャーナルIEEE Access
出版ステータス出版済み - 2021

!!!All Science Journal Classification (ASJC) codes

  • コンピュータ サイエンス(全般)
  • 材料科学(全般)
  • 工学(全般)


「Micro-LED Array-Based Photo-Stimulation Devices for Optogenetics in Rat and Macaque Monkey Brains」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。