Microarray data on altered transcriptional program of Phgdh-deficient mouse embryonic fibroblasts caused by L-serine depletion

Momoko Hamano, Tomoko Sayano, Wataru Kusada, Hisanori Kato, Shigeki Furuya

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Inherent L-Ser deficiency culminates in intrauterine growth retardation, severe malformation of multiple organs particularly the central nervous system, and perinatal or early postnatal death in human and mouse. To uncover the molecular mechanisms underlying the growth-arrested phenotypes of l-Ser deficiency, we compared gene expression profiles of mouse embryonic fibroblasts deficient in 3-phosphoglycerate dehydrogenase (Phgdh), the first enzyme of de novo L-Ser synthetic pathway, between L-Ser-depleted and -supplemented conditions. The datasets (CEL and CHP files) from this study are publicly available on the Gene Expression Omnibus repository (accession number GEO: GSE55687).

本文言語英語
ページ(範囲)1598-1601
ページ数4
ジャーナルData in Brief
7
DOI
出版ステータス出版済み - 6 1 2016

All Science Journal Classification (ASJC) codes

  • General

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