Microfabrication and microfluidic devices for drug delivery

Niko Kimura, Masatoshi Maeki, Manabu Tokeshi

研究成果: 書籍/レポート タイプへの寄稿

7 被引用数 (Scopus)

抄録

Carrier-assist drug delivery systems (DDSs) have been developed to improve the present problems of the cancer chemotherapies. In the developed several types of DDS carriers, lipid nanoparticles (LNPs) are the most widely used for the cancer chemotherapy. Although LNPs have high biocompatibility and good circulation time in blood, precise size control of LNPs in the size range of 20-100 nm is required for the cancer therapy applications. Microfluidic devices will be key apparatus to achieve the size-controlled LNP synthesis. A microfluidic device with micromixer structures also plays important role for the LNP production, because it enables rapid mixing of lipid solution and aqueous solution for precise LNP size control. This chapter provides the microfluidic-based LNP production methods from the device fabrication to DDS applications.

本文言語英語
ホスト出版物のタイトルMicrofluidics for Pharmaceutical Applications
ホスト出版物のサブタイトルFrom Nano/Micro Systems Fabrication to Controlled Drug Delivery
出版社Elsevier
ページ123-136
ページ数14
ISBN(電子版)9780128126592
ISBN(印刷版)9780128126608
DOI
出版ステータス出版済み - 1月 1 2018
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 化学 (全般)

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