Microfluidic approach for production of lipid nanoparticles-based nano medicine

M. Maeki, T. Saito, Y. Node, Y. Sato, T. Yasui, N. Kaji, A. Ishida, H. Tani, Y. Baba, H. Harashima, M. Tokeshi

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

1 被引用数 (Scopus)

抄録

This paper described a simple preparation method for small-size and monodispersed lipid nanoparticles (LNPs) by using microfluidic devices. The fundamental role and importance of chaotic micromixer in the microfluidic device was demonstrated. The suitable cycle number of chaotic micromixer was confirmed for precise controlling LNPs size with narrow distribution under the any flow rate conditions. In addition, LNPs containing siRNA was synthesized for evaluation of penetration efficiency via in vivo experiment. The PEGylated LNPs containing siRNA with a diameter of 30 nm could penetrate to the mouse parenchymal liver cells rather than the LNPs with a diameter of 50 nm.

本文言語英語
ホスト出版物のタイトルMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
出版社Chemical and Biological Microsystems Society
ページ838-840
ページ数3
ISBN(電子版)9780979806483
出版ステータス出版済み - 2015
外部発表はい
イベント19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, 大韓民国
継続期間: 10 25 201510 29 2015

出版物シリーズ

名前MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

その他

その他19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
国/地域大韓民国
CityGyeongju
Period10/25/1510/29/15

All Science Journal Classification (ASJC) codes

  • 制御およびシステム工学

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