Microfluidic approach for production of lipid nanoparticles-based nano medicine

M. Maeki, T. Saito, Y. Node, Y. Sato, T. Yasui, N. Kaji, A. Ishida, H. Tani, Y. Baba, H. Harashima, M. Tokeshi

研究成果: 著書/レポートタイプへの貢献会議での発言

抄録

This paper described a simple preparation method for small-size and monodispersed lipid nanoparticles (LNPs) by using microfluidic devices. The fundamental role and importance of chaotic micromixer in the microfluidic device was demonstrated. The suitable cycle number of chaotic micromixer was confirmed for precise controlling LNPs size with narrow distribution under the any flow rate conditions. In addition, LNPs containing siRNA was synthesized for evaluation of penetration efficiency via in vivo experiment. The PEGylated LNPs containing siRNA with a diameter of 30 nm could penetrate to the mouse parenchymal liver cells rather than the LNPs with a diameter of 50 nm.

元の言語英語
ホスト出版物のタイトルMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
出版者Chemical and Biological Microsystems Society
ページ838-840
ページ数3
ISBN(電子版)9780979806483
出版物ステータス出版済み - 1 1 2015
外部発表Yes
イベント19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, 大韓民国
継続期間: 10 25 201510 29 2015

出版物シリーズ

名前MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

その他

その他19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
大韓民国
Gyeongju
期間10/25/1510/29/15

Fingerprint

Medical nanotechnology
Microfluidics
Lipids
Nanoparticles
Liver
Flow rate
Experiments

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

これを引用

Maeki, M., Saito, T., Node, Y., Sato, Y., Yasui, T., Kaji, N., ... Tokeshi, M. (2015). Microfluidic approach for production of lipid nanoparticles-based nano medicine. : MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 838-840). (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.

Microfluidic approach for production of lipid nanoparticles-based nano medicine. / Maeki, M.; Saito, T.; Node, Y.; Sato, Y.; Yasui, T.; Kaji, N.; Ishida, A.; Tani, H.; Baba, Y.; Harashima, H.; Tokeshi, M.

MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. p. 838-840 (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

研究成果: 著書/レポートタイプへの貢献会議での発言

Maeki, M, Saito, T, Node, Y, Sato, Y, Yasui, T, Kaji, N, Ishida, A, Tani, H, Baba, Y, Harashima, H & Tokeshi, M 2015, Microfluidic approach for production of lipid nanoparticles-based nano medicine. : MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 838-840, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, Gyeongju, 大韓民国, 10/25/15.
Maeki M, Saito T, Node Y, Sato Y, Yasui T, Kaji N その他. Microfluidic approach for production of lipid nanoparticles-based nano medicine. : MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2015. p. 838-840. (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).
Maeki, M. ; Saito, T. ; Node, Y. ; Sato, Y. ; Yasui, T. ; Kaji, N. ; Ishida, A. ; Tani, H. ; Baba, Y. ; Harashima, H. ; Tokeshi, M. / Microfluidic approach for production of lipid nanoparticles-based nano medicine. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. pp. 838-840 (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).
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