Microfluidic Separation of Redox Reactions for Coulometry Based on Metallization at the Mixed Potential

Kazuhiro Ikemoto, Takafumi Seki, Shohei Kimura, Yui Nakaoka, Shinnosuke Tsuchiya, Fumihiro Sassa, Masatoshi Yokokawa, Hiroaki Suzuki

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

Coulometric detection of an analyte in a solution at nanoliter scale was conducted by having redox reactions proceed simultaneously on a platinum electrode. The analyte was oxidized on a part of the electrode in one flow channel and silver was deposited on an array of circular microelectrodes formed in another flow channel at a mixed potential. Coulometric determination of the deposited silver showed a steep change in the generated charge as a result of the complete oxidation of silver. The short measurement time after the start of the coulometry suppressed the increase in background charge, resulting in significant lowering of the detection limit. The lower detection limit for H2O2 was 30 nM (3σ). To improve selectivity and minimize the influence of coexisting interferents, the shifting of the mixed potential, application of a permselective membrane, and electrochemical elimination of the interferents were effective modifications.

本文言語英語
ページ(範囲)9427-9434
ページ数8
ジャーナルAnalytical Chemistry
88
19
DOI
出版ステータス出版済み - 10 4 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分析化学

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