Microfluidic visualization of encounter complex in enzymatic digestion of single DNA molecule by dual molecular tagging

D. Onoshima, N. Kaji, M. Tokeshi, Y. Baba

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

We combined molecular tagging with microfluidics to study kinematics in a single DNA molecular digestion. Moving tags of both DNA ends revealed initial breakup of a single DNA molecule into fragments induced by limited enzymatic digestion and subsequent rapid formation of transient structure in encounter complex. The method enables us to analyze rapid dissociation of weakly bound complexes derived from intramolecular transfer.

本文言語英語
ホスト出版物のタイトル15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
ページ2061-2063
ページ数3
出版ステータス出版済み - 12 1 2011
外部発表はい
イベント15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, 米国
継続期間: 10 2 201110 6 2011

出版物シリーズ

名前15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
3

その他

その他15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Country米国
CitySeattle, WA
Period10/2/1110/6/11

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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