Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging

Hiroshi Nakanishi, Hiro Take

研究成果: ジャーナルへの寄稿評論記事

84 引用 (Scopus)

抄録

The accumulation of lysosome- and mitochondria-derived reactive oxygen species (ROS) are the most important causative factors for aging. Autophagic dysfunction and mitochondrial DNA damage in the central nervous system (CNS) are prominently found in microglia, the resident mononuclear phagocyte population within the CNS. The autophagic dysfunction may induce the defective turnover of mitochondria, which results in the accumulation of ROS-hypergenerating older mitochondria in microglia. ROS activate redox-dependent transduction cascades and transcription factors, including nuclear factor-κB, which induce the expression of inflammatory genes. Therefore, "microglia-aging" could function as a major driver for brain aging. Furthermore, the prevention of lysosomal autophagic dysfunction and mitochondrial DNA damage in microglia may therefore be a potentially effective new pharmaceutical intervention against brain aging.

元の言語英語
ページ(範囲)1-7
ページ数7
ジャーナルBehavioural Brain Research
201
発行部数1
DOI
出版物ステータス出版済み - 7 19 2009

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Microglia
Lysosomes
Reactive Oxygen Species
Mitochondria
Brain
Mitochondrial DNA
DNA Damage
Central Nervous System
Phagocytes
Oxidation-Reduction
Transcription Factors
Gene Expression
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

これを引用

Microglia-aging : Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging. / Nakanishi, Hiroshi; Take, Hiro.

:: Behavioural Brain Research, 巻 201, 番号 1, 19.07.2009, p. 1-7.

研究成果: ジャーナルへの寄稿評論記事

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