Microglial hypothesis of schizophrenia

Shigenobu Kanba, Takahiro Kato

研究成果: Contribution to journalReview article査読

2 被引用数 (Scopus)

抄録

While the etiology of schizophrenia remains unclear, there has been a growing amount of evidence pointing to neuroinflammation, which is characterized by an increased serum concentration of several pro-inflammatory cytokines and an increase of microglia in the brain of schizophrenics. Microglia respond rapidly to even minor pathological changes in the brain and may contribute directly to neuronal degeneration by producing various pro-inflammatory cytokines and free radicals. In many aspects, the neuropathology of schizophrenia has recently been reported to be closely associated with microglial activation. Our "Microglia Hypothesis of Schizophrenia" may shed a new light on the therapeutic strategy for schizophrenia.

本文言語英語
ページ(範囲)11-13
ページ数3
ジャーナルJapanese Journal of Neuropsychopharmacology
34
1
出版ステータス出版済み - 2 2014

All Science Journal Classification (ASJC) codes

  • 臨床心理学
  • 薬理学
  • 精神医学および精神衛生
  • 薬理学(医学)

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