抄録
Detecting of cell-free circulating methylated DNA could be a promising method for early diagnosis of cancer. Here we have developed the microheater - zinc oxide nanowires (ZnO-NWs) structures embedded in the microchannel device for capturing DNA via electrostatic interaction. We found that 60% of DNA could be captured on ZnO-NWs. Additionally, the microheater, which constantly enables to generate heat, can denature double stranded DNA (dsDNA) to single stranded DNA (ssDNA). Finally, ICON Probe, which is an artificial ssDNA probe for DNA methylation, was introduced inside a device to bind to ssDNA for DNA methylation detection.
| 本文言語 | 英語 |
|---|---|
| ホスト出版物のタイトル | 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 |
| 出版社 | Chemical and Biological Microsystems Society |
| ページ | 1886-1888 |
| ページ数 | 3 |
| ISBN（電子版） | 9781510897571 |
| 出版ステータス | 出版済み - 1月 1 2018 |
| イベント | 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, 台湾 継続期間: 11月 11 2018 → 11月 15 2018 |
出版物シリーズ
| 名前 | 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 |
|---|---|
| 巻 | 4 |
会議
| 会議 | 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 |
|---|---|
| 国/地域 | 台湾 |
| City | Kaohsiung |
| Period | 11/11/18 → 11/15/18 |
!!!All Science Journal Classification (ASJC) codes
- 化学 (全般)
- バイオエンジニアリング
- 化学工学（その他）
- 制御およびシステム工学
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
