MicroRNAs as biomarkers in colorectal cancer

Takaaki Masuda, Naoki Hayashi, Yosuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Koshi Mimori

研究成果: ジャーナルへの寄稿評論記事

43 引用 (Scopus)

抄録

MicroRNAs (miRs) are small RNAs that repress mRNA translation, resulting in the degradation of mRNAs and regulation of the expression levels of various genes. Recent studies have shown that aberrant miR expression has a functional role in the initiation and progression of various malignancies, including colorectal cancer (CRC), which is one of the leading causes of cancer-related death worldwide. miRs have also been shown to have applications as diagnostic, prognostic, and predictive biomarkers because of their high tissue specificity, stability, and altered expression in tumor development. In this report, we examined the role of miRs as biomarkers in CRC through a review of meta-analyses and large-scale analyses having strong statistical confidence in the study outcomes. We also discuss current issues in the clinical application of these miRs.

元の言語英語
記事番号124
ジャーナルCancers
9
発行部数9
DOI
出版物ステータス出版済み - 9 13 2017

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MicroRNAs
Colorectal Neoplasms
Biomarkers
Neoplasms
Organ Specificity
RNA Stability
Protein Biosynthesis
Meta-Analysis
Outcome Assessment (Health Care)
RNA
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

MicroRNAs as biomarkers in colorectal cancer. / Masuda, Takaaki; Hayashi, Naoki; Kuroda, Yosuke; Ito, Shuhei; Eguchi, Hidetoshi; Mimori, Koshi.

:: Cancers, 巻 9, 番号 9, 124, 13.09.2017.

研究成果: ジャーナルへの寄稿評論記事

Masuda, T, Hayashi, N, Kuroda, Y, Ito, S, Eguchi, H & Mimori, K 2017, 'MicroRNAs as biomarkers in colorectal cancer', Cancers, 巻. 9, 番号 9, 124. https://doi.org/10.3390/cancers9090124
Masuda, Takaaki ; Hayashi, Naoki ; Kuroda, Yosuke ; Ito, Shuhei ; Eguchi, Hidetoshi ; Mimori, Koshi. / MicroRNAs as biomarkers in colorectal cancer. :: Cancers. 2017 ; 巻 9, 番号 9.
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