Midkine mRNA is overexpressed in pancreatic cancer

Seiji Ohhashi, Kenoki Ohuchida, Kazuhiro Mizumoto, Takuya Egami, Jun Yu, Lin Cui, Hiroki Toma, Shunichi Takahata, Toshinaga Nabae, Masao Tanaka

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

抄録

Purpose Midkine (MK) has been reported to be a possible molecular marker for the diagnosis of pancreatic cancer. We investigated the feasibility of quantitative analysis of MK mRNA by quantitative real-time RT-PCR (qRT-PCR) as a promising tool for the diagnosis of pancreatic cancer. Results We found that pancreatic cancer tissues expressed significantly higher levels of MK mRNA than intraductal pancreatic mucinous neoplasm (IPMN) and non-neoplastic pancreatic tissues (P < 0.05); in contrast, we did not find any differences in MK mRNA expression between IPMN and non-neoplastic pancreatic tissues. Additionally, we observed that poorly differentiated carcinoma samples expressed higher levels of MK mRNA than well-differentiated carcinoma samples, although a significant difference was not observed. Conclusions The present data suggests that quantitative analysis of MK mRNA provides an objective and sensitive evaluation and may be a promising modality for the diagnosis of pancreatic cancer and the prediction of its prognosis.

元の言語英語
ページ(範囲)811-815
ページ数5
ジャーナルDigestive Diseases and Sciences
54
発行部数4
DOI
出版物ステータス出版済み - 4 1 2009

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Pancreatic Neoplasms
Messenger RNA
Carcinoma
midkine
Real-Time Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

これを引用

Midkine mRNA is overexpressed in pancreatic cancer. / Ohhashi, Seiji; Ohuchida, Kenoki; Mizumoto, Kazuhiro; Egami, Takuya; Yu, Jun; Cui, Lin; Toma, Hiroki; Takahata, Shunichi; Nabae, Toshinaga; Tanaka, Masao.

:: Digestive Diseases and Sciences, 巻 54, 番号 4, 01.04.2009, p. 811-815.

研究成果: ジャーナルへの寄稿記事

Ohhashi, S, Ohuchida, K, Mizumoto, K, Egami, T, Yu, J, Cui, L, Toma, H, Takahata, S, Nabae, T & Tanaka, M 2009, 'Midkine mRNA is overexpressed in pancreatic cancer', Digestive Diseases and Sciences, 巻. 54, 番号 4, pp. 811-815. https://doi.org/10.1007/s10620-008-0434-4
Ohhashi, Seiji ; Ohuchida, Kenoki ; Mizumoto, Kazuhiro ; Egami, Takuya ; Yu, Jun ; Cui, Lin ; Toma, Hiroki ; Takahata, Shunichi ; Nabae, Toshinaga ; Tanaka, Masao. / Midkine mRNA is overexpressed in pancreatic cancer. :: Digestive Diseases and Sciences. 2009 ; 巻 54, 番号 4. pp. 811-815.
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abstract = "Purpose Midkine (MK) has been reported to be a possible molecular marker for the diagnosis of pancreatic cancer. We investigated the feasibility of quantitative analysis of MK mRNA by quantitative real-time RT-PCR (qRT-PCR) as a promising tool for the diagnosis of pancreatic cancer. Results We found that pancreatic cancer tissues expressed significantly higher levels of MK mRNA than intraductal pancreatic mucinous neoplasm (IPMN) and non-neoplastic pancreatic tissues (P < 0.05); in contrast, we did not find any differences in MK mRNA expression between IPMN and non-neoplastic pancreatic tissues. Additionally, we observed that poorly differentiated carcinoma samples expressed higher levels of MK mRNA than well-differentiated carcinoma samples, although a significant difference was not observed. Conclusions The present data suggests that quantitative analysis of MK mRNA provides an objective and sensitive evaluation and may be a promising modality for the diagnosis of pancreatic cancer and the prediction of its prognosis.",
author = "Seiji Ohhashi and Kenoki Ohuchida and Kazuhiro Mizumoto and Takuya Egami and Jun Yu and Lin Cui and Hiroki Toma and Shunichi Takahata and Toshinaga Nabae and Masao Tanaka",
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T1 - Midkine mRNA is overexpressed in pancreatic cancer

AU - Ohhashi, Seiji

AU - Ohuchida, Kenoki

AU - Mizumoto, Kazuhiro

AU - Egami, Takuya

AU - Yu, Jun

AU - Cui, Lin

AU - Toma, Hiroki

AU - Takahata, Shunichi

AU - Nabae, Toshinaga

AU - Tanaka, Masao

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Purpose Midkine (MK) has been reported to be a possible molecular marker for the diagnosis of pancreatic cancer. We investigated the feasibility of quantitative analysis of MK mRNA by quantitative real-time RT-PCR (qRT-PCR) as a promising tool for the diagnosis of pancreatic cancer. Results We found that pancreatic cancer tissues expressed significantly higher levels of MK mRNA than intraductal pancreatic mucinous neoplasm (IPMN) and non-neoplastic pancreatic tissues (P < 0.05); in contrast, we did not find any differences in MK mRNA expression between IPMN and non-neoplastic pancreatic tissues. Additionally, we observed that poorly differentiated carcinoma samples expressed higher levels of MK mRNA than well-differentiated carcinoma samples, although a significant difference was not observed. Conclusions The present data suggests that quantitative analysis of MK mRNA provides an objective and sensitive evaluation and may be a promising modality for the diagnosis of pancreatic cancer and the prediction of its prognosis.

AB - Purpose Midkine (MK) has been reported to be a possible molecular marker for the diagnosis of pancreatic cancer. We investigated the feasibility of quantitative analysis of MK mRNA by quantitative real-time RT-PCR (qRT-PCR) as a promising tool for the diagnosis of pancreatic cancer. Results We found that pancreatic cancer tissues expressed significantly higher levels of MK mRNA than intraductal pancreatic mucinous neoplasm (IPMN) and non-neoplastic pancreatic tissues (P < 0.05); in contrast, we did not find any differences in MK mRNA expression between IPMN and non-neoplastic pancreatic tissues. Additionally, we observed that poorly differentiated carcinoma samples expressed higher levels of MK mRNA than well-differentiated carcinoma samples, although a significant difference was not observed. Conclusions The present data suggests that quantitative analysis of MK mRNA provides an objective and sensitive evaluation and may be a promising modality for the diagnosis of pancreatic cancer and the prediction of its prognosis.

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