Midline crossing and Slit responsiveness of commissural axons require USP33

Junichi Yuasa-Kawada, Mariko Kinoshita-Kawada, Guan Wu, Yi Rao, Jane Y. Wu

    研究成果: Contribution to journalArticle査読

    35 被引用数 (Scopus)

    抄録

    Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.

    本文言語英語
    ページ(範囲)1087-1089
    ページ数3
    ジャーナルNature Neuroscience
    12
    9
    DOI
    出版ステータス出版済み - 9 2009

    All Science Journal Classification (ASJC) codes

    • 神経科学(全般)

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