Minimally-invasive local injection by electrically-driven narrow orifice channel

Kazuki Takahashi, Shun Omi, Yoko Yamanishi

研究成果: 著書/レポートタイプへの貢献会議での発言

抄録

We have successfully developed minimally-invasive needle-free bubble injector designed for the usage in air. The novelty is that the minimally-invasiveness of injection whose resolution is less than 10 μm, and hence cellular-scale injection can be possible without any pain. The novelty of the present techniques are (1) unique robust thick structure at the tip of the narrowed glass capillary for operation in air, (2) damper structure produce closed space to fill in reagent which enabled the injector to be used in air and (3) construction part to support inner probe to make self-aligned coaxial positioning for accurate injection. The injector can be used for any kind of materials with various hardness, owing to the strong impact of cavitation phenomenon when the high-speed micro-bubbles are collapsed. The fine adjustment of injection can be controlled by the number of applied electric pulses. The developed injector can be used for wide range of biomedical study, especially in gene therapy. This technique has advantages over the conventional electroporation or ultrasound operation in terms of localization of injection and ability of transportation of material.

元の言語英語
ホスト出版物のタイトル2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014
出版者Institute of Electrical and Electronics Engineers Inc.
ISBN(電子版)9781479966790
DOI
出版物ステータス出版済み - 1 9 2015
イベント2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014 - Nagoya, 日本
継続期間: 11 10 201411 12 2014

出版物シリーズ

名前2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014

その他

その他2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014
日本
Nagoya
期間11/10/1411/12/14

Fingerprint

Orifices
Air
Gene therapy
Bubbles (in fluids)
Cavitation
Needles
Ultrasonics
Hardness
Glass

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Mechanical Engineering

これを引用

Takahashi, K., Omi, S., & Yamanishi, Y. (2015). Minimally-invasive local injection by electrically-driven narrow orifice channel. : 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014 [7006059] (2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MHS.2014.7006059

Minimally-invasive local injection by electrically-driven narrow orifice channel. / Takahashi, Kazuki; Omi, Shun; Yamanishi, Yoko.

2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014. Institute of Electrical and Electronics Engineers Inc., 2015. 7006059 (2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014).

研究成果: 著書/レポートタイプへの貢献会議での発言

Takahashi, K, Omi, S & Yamanishi, Y 2015, Minimally-invasive local injection by electrically-driven narrow orifice channel. : 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014., 7006059, 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014, Institute of Electrical and Electronics Engineers Inc., 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014, Nagoya, 日本, 11/10/14. https://doi.org/10.1109/MHS.2014.7006059
Takahashi K, Omi S, Yamanishi Y. Minimally-invasive local injection by electrically-driven narrow orifice channel. : 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014. Institute of Electrical and Electronics Engineers Inc. 2015. 7006059. (2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014). https://doi.org/10.1109/MHS.2014.7006059
Takahashi, Kazuki ; Omi, Shun ; Yamanishi, Yoko. / Minimally-invasive local injection by electrically-driven narrow orifice channel. 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014. Institute of Electrical and Electronics Engineers Inc., 2015. (2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014).
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