Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche

Yoku Hayakawa, hiroshi ariyama, Jitka Stancikova, Kosuke Sakitani, Samuel Asfaha, Bernhard W. Renz, Zinaida A. Dubeykovskaya, Wataru Shibata, Hongshan Wang, Christoph B. Westphalen, Xiaowei Chen, Yoshihiro Takemoto, Woosook Kim, Shradha S. Khurana, Yagnesh Tailor, Karan Nagar, Hiroyuki Tomita, Akira Hara, Antonia R. Sepulveda, Wanda Setlik & 10 others Michael D. Gershon, Subhrajit Saha, Lei Ding, Zeli Shen, James G. Fox, Richard A. Friedman, Stephen F. Konieczny, Daniel L. Worthley, Vladimir Korinek, Timothy C. Wang

研究成果: ジャーナルへの寄稿記事

102 引用 (Scopus)

抄録

The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1+ stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin. Diffuse-type cancer development is dependent on inflammation mediated by Cxcl12+ endothelial cells and Cxcr4+ gastric innate lymphoid cells (ILCs). These cells form the perivascular gastric stem cell niche, and Wnt5a produced from ILCs activates RhoA to inhibit anoikis in the E-cadherin-depleted cells. Targeting Cxcr4, ILCs, or Wnt5a inhibits diffuse-type gastric carcinogenesis, providing targets within the neoplastic gastric stem cell niche.

元の言語英語
ページ(範囲)800-814
ページ数15
ジャーナルCancer Cell
28
発行部数6
DOI
出版物ステータス出版済み - 12 14 2015
外部発表Yes

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Stem Cell Niche
Stomach
Stem Cells
Epithelium
Lymphocytes
Cadherins
Anoikis
Intestinal Neoplasms
Neoplastic Stem Cells
Gastric Mucosa
Neoplasms
Carcinogenesis
Endothelial Cells
Inflammation
Mutation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cell Biology
  • Cancer Research

これを引用

Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. / Hayakawa, Yoku; ariyama, hiroshi; Stancikova, Jitka; Sakitani, Kosuke; Asfaha, Samuel; Renz, Bernhard W.; Dubeykovskaya, Zinaida A.; Shibata, Wataru; Wang, Hongshan; Westphalen, Christoph B.; Chen, Xiaowei; Takemoto, Yoshihiro; Kim, Woosook; Khurana, Shradha S.; Tailor, Yagnesh; Nagar, Karan; Tomita, Hiroyuki; Hara, Akira; Sepulveda, Antonia R.; Setlik, Wanda; Gershon, Michael D.; Saha, Subhrajit; Ding, Lei; Shen, Zeli; Fox, James G.; Friedman, Richard A.; Konieczny, Stephen F.; Worthley, Daniel L.; Korinek, Vladimir; Wang, Timothy C.

:: Cancer Cell, 巻 28, 番号 6, 14.12.2015, p. 800-814.

研究成果: ジャーナルへの寄稿記事

Hayakawa, Y, ariyama, H, Stancikova, J, Sakitani, K, Asfaha, S, Renz, BW, Dubeykovskaya, ZA, Shibata, W, Wang, H, Westphalen, CB, Chen, X, Takemoto, Y, Kim, W, Khurana, SS, Tailor, Y, Nagar, K, Tomita, H, Hara, A, Sepulveda, AR, Setlik, W, Gershon, MD, Saha, S, Ding, L, Shen, Z, Fox, JG, Friedman, RA, Konieczny, SF, Worthley, DL, Korinek, V & Wang, TC 2015, 'Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche', Cancer Cell, 巻. 28, 番号 6, pp. 800-814. https://doi.org/10.1016/j.ccell.2015.10.003
Hayakawa, Yoku ; ariyama, hiroshi ; Stancikova, Jitka ; Sakitani, Kosuke ; Asfaha, Samuel ; Renz, Bernhard W. ; Dubeykovskaya, Zinaida A. ; Shibata, Wataru ; Wang, Hongshan ; Westphalen, Christoph B. ; Chen, Xiaowei ; Takemoto, Yoshihiro ; Kim, Woosook ; Khurana, Shradha S. ; Tailor, Yagnesh ; Nagar, Karan ; Tomita, Hiroyuki ; Hara, Akira ; Sepulveda, Antonia R. ; Setlik, Wanda ; Gershon, Michael D. ; Saha, Subhrajit ; Ding, Lei ; Shen, Zeli ; Fox, James G. ; Friedman, Richard A. ; Konieczny, Stephen F. ; Worthley, Daniel L. ; Korinek, Vladimir ; Wang, Timothy C. / Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. :: Cancer Cell. 2015 ; 巻 28, 番号 6. pp. 800-814.
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abstract = "The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1+ stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin. Diffuse-type cancer development is dependent on inflammation mediated by Cxcl12+ endothelial cells and Cxcr4+ gastric innate lymphoid cells (ILCs). These cells form the perivascular gastric stem cell niche, and Wnt5a produced from ILCs activates RhoA to inhibit anoikis in the E-cadherin-depleted cells. Targeting Cxcr4, ILCs, or Wnt5a inhibits diffuse-type gastric carcinogenesis, providing targets within the neoplastic gastric stem cell niche.",
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AU - Stancikova, Jitka

AU - Sakitani, Kosuke

AU - Asfaha, Samuel

AU - Renz, Bernhard W.

AU - Dubeykovskaya, Zinaida A.

AU - Shibata, Wataru

AU - Wang, Hongshan

AU - Westphalen, Christoph B.

AU - Chen, Xiaowei

AU - Takemoto, Yoshihiro

AU - Kim, Woosook

AU - Khurana, Shradha S.

AU - Tailor, Yagnesh

AU - Nagar, Karan

AU - Tomita, Hiroyuki

AU - Hara, Akira

AU - Sepulveda, Antonia R.

AU - Setlik, Wanda

AU - Gershon, Michael D.

AU - Saha, Subhrajit

AU - Ding, Lei

AU - Shen, Zeli

AU - Fox, James G.

AU - Friedman, Richard A.

AU - Konieczny, Stephen F.

AU - Worthley, Daniel L.

AU - Korinek, Vladimir

AU - Wang, Timothy C.

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