抄録
Mitochondria, cellular powerhouses of eukaryotes, are known to act as central hubs for multiple signal transductions. Recent research reveals that mitochondria are involved in cellular innate antiviral immunity in vertebrates, particularly mammals. Mitochondrial-mediated antiviral immunity depends on the activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and on the participation of a mitochondrial outer membrane adaptor protein, called the "mitochondrial antiviral signaling (MAVS)". In this review, we discuss unexpected discoveries that are revealing how the organelles contribute to the innate immune response against RNA viruses. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 225-232 |
| ページ数 | 8 |
| ジャーナル | Biochimica et Biophysica Acta - Molecular Cell Research |
| 巻 | 1833 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | 出版済み - 1 1 2013 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology
これを引用
Mitochondrial-mediated antiviral immunity. / Koshiba, Takumi.
：: Biochimica et Biophysica Acta - Molecular Cell Research, 巻 1833, 番号 1, 01.01.2013, p. 225-232.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Mitochondrial-mediated antiviral immunity
AU - Koshiba, Takumi
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Mitochondria, cellular powerhouses of eukaryotes, are known to act as central hubs for multiple signal transductions. Recent research reveals that mitochondria are involved in cellular innate antiviral immunity in vertebrates, particularly mammals. Mitochondrial-mediated antiviral immunity depends on the activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and on the participation of a mitochondrial outer membrane adaptor protein, called the "mitochondrial antiviral signaling (MAVS)". In this review, we discuss unexpected discoveries that are revealing how the organelles contribute to the innate immune response against RNA viruses. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology.
AB - Mitochondria, cellular powerhouses of eukaryotes, are known to act as central hubs for multiple signal transductions. Recent research reveals that mitochondria are involved in cellular innate antiviral immunity in vertebrates, particularly mammals. Mitochondrial-mediated antiviral immunity depends on the activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and on the participation of a mitochondrial outer membrane adaptor protein, called the "mitochondrial antiviral signaling (MAVS)". In this review, we discuss unexpected discoveries that are revealing how the organelles contribute to the innate immune response against RNA viruses. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology.
UR - http://www.scopus.com/inward/record.url?scp=84871807864&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871807864&partnerID=8YFLogxK
U2 - 10.1016/j.bbamcr.2012.03.005
DO - 10.1016/j.bbamcr.2012.03.005
M3 - Review article
C2 - 22440325
AN - SCOPUS:84871807864
VL - 1833
SP - 225
EP - 232
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
SN - 0167-4889
IS - 1
ER -