Mitochondrial-mediated antiviral immunity

Takumi Koshiba

研究成果: ジャーナルへの寄稿総説査読

86 被引用数 (Scopus)

抄録

Mitochondria, cellular powerhouses of eukaryotes, are known to act as central hubs for multiple signal transductions. Recent research reveals that mitochondria are involved in cellular innate antiviral immunity in vertebrates, particularly mammals. Mitochondrial-mediated antiviral immunity depends on the activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and on the participation of a mitochondrial outer membrane adaptor protein, called the "mitochondrial antiviral signaling (MAVS)". In this review, we discuss unexpected discoveries that are revealing how the organelles contribute to the innate immune response against RNA viruses. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology.

本文言語英語
ページ(範囲)225-232
ページ数8
ジャーナルBiochimica et Biophysica Acta - Molecular Cell Research
1833
1
DOI
出版ステータス出版済み - 1月 2013

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 細胞生物学

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