Mitochondrial-mediated antiviral immunity

Takumi Koshiba

研究成果: ジャーナルへの寄稿評論記事

57 引用 (Scopus)

抄録

Mitochondria, cellular powerhouses of eukaryotes, are known to act as central hubs for multiple signal transductions. Recent research reveals that mitochondria are involved in cellular innate antiviral immunity in vertebrates, particularly mammals. Mitochondrial-mediated antiviral immunity depends on the activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and on the participation of a mitochondrial outer membrane adaptor protein, called the "mitochondrial antiviral signaling (MAVS)". In this review, we discuss unexpected discoveries that are revealing how the organelles contribute to the innate immune response against RNA viruses. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology.

元の言語英語
ページ(範囲)225-232
ページ数8
ジャーナルBiochimica et Biophysica Acta - Molecular Cell Research
1833
発行部数1
DOI
出版物ステータス出版済み - 1 1 2013

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Antiviral Agents
Immunity
Innate Immunity
Signal Transduction
Mitochondria
Mitochondrial Dynamics
RNA Viruses
Tretinoin
Eukaryota
Cellular Immunity
Organelles
Vertebrates
Mammals
Membrane Proteins
Research
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

これを引用

Mitochondrial-mediated antiviral immunity. / Koshiba, Takumi.

:: Biochimica et Biophysica Acta - Molecular Cell Research, 巻 1833, 番号 1, 01.01.2013, p. 225-232.

研究成果: ジャーナルへの寄稿評論記事

Koshiba, Takumi. / Mitochondrial-mediated antiviral immunity. :: Biochimica et Biophysica Acta - Molecular Cell Research. 2013 ; 巻 1833, 番号 1. pp. 225-232.
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