Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45 TER119Erythroid and Lymphoid Progenitors

研究成果: Contribution to journalArticle査読

抄録

p32/C1qbp regulates mitochondrial protein synthesis and is essential for oxidative phosphorylation in mitochondria. Although dysfunction of p32/C1qbp impairs fetal development and immune responses, its role in hematopoietic differentiation remains unclear. Here, we found that mitochondrial dysfunction affected terminal differentiation of newly identified erythroid/B-lymphoid progenitors among CD45 Ter119 CD31 triple-negative cells (TNCs) in bone marrow. Hematopoietic cell-specific genetic deletion of p32/C1qbp (p32cKO) in mice caused anemia and B-lymphopenia without reduction of hematopoietic stem/progenitor cells. In addition, p32cKO mice were susceptible to hematopoietic stress with delayed recovery from anemia. p32/C1qbp-deficient CD51 TNCs exhibited impaired mitochondrial oxidation that consequently led to inactivation of mTORC1 signaling, which is essential for erythropoiesis. These findings uncover the importance of mitochondria, especially at the stage of TNCs during erythropoiesis, suggesting that dysregulation of mitochondrial protein synthesis is a cause of anemia and B-lymphopenia with an unknown pathology.

本文言語英語
論文番号101654
ジャーナルiScience
23
11
DOI
出版ステータス出版済み - 11 20 2020

All Science Journal Classification (ASJC) codes

  • General

フィンガープリント 「Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45<sup>–</sup> TER119<sup>–</sup>Erythroid and Lymphoid Progenitors」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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