Mitral annular remodeling to treat functional mitral regurgitation: A pilot acute study in a canine model

Hideyuki Fumoto, Tohru Takaseya, Akira Shiose, Roberto M. Saraiva, Yoko Arakawa, Margaret Park, Santosh Rao, Raymond Dessoffy, Ji Feng Chen, Qun Zhou, Anthony Calabro, Michael Banbury, Kiyotaka Fukamachi

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Background: The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR). Methods: Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection. Results: The injection improved MR grade from 3.4 ± 0.8 to 1.3 ± 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 ± 0.4 cm to 2.9 ± 0.3 cm; P = .039) and MR volume (20.6 ± 7.3 mm3 to 5.2 ± 2.2 mm3; P = .044). Conclusions: A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model.

元の言語英語
ジャーナルHeart Surgery Forum
13
発行部数4
DOI
出版物ステータス出版済み - 8 1 2010

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Mitral Valve Insufficiency
Canidae
Hydrogel
Heart Ventricles
Injections
Tyramine
Papillary Muscles
Hyaluronic Acid
Myocardial Ischemia
Echocardiography
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

これを引用

Mitral annular remodeling to treat functional mitral regurgitation : A pilot acute study in a canine model. / Fumoto, Hideyuki; Takaseya, Tohru; Shiose, Akira; Saraiva, Roberto M.; Arakawa, Yoko; Park, Margaret; Rao, Santosh; Dessoffy, Raymond; Chen, Ji Feng; Zhou, Qun; Calabro, Anthony; Banbury, Michael; Fukamachi, Kiyotaka.

:: Heart Surgery Forum, 巻 13, 番号 4, 01.08.2010.

研究成果: ジャーナルへの寄稿記事

Fumoto, H, Takaseya, T, Shiose, A, Saraiva, RM, Arakawa, Y, Park, M, Rao, S, Dessoffy, R, Chen, JF, Zhou, Q, Calabro, A, Banbury, M & Fukamachi, K 2010, 'Mitral annular remodeling to treat functional mitral regurgitation: A pilot acute study in a canine model', Heart Surgery Forum, 巻. 13, 番号 4. https://doi.org/10.1532/HSF98.20101003
Fumoto, Hideyuki ; Takaseya, Tohru ; Shiose, Akira ; Saraiva, Roberto M. ; Arakawa, Yoko ; Park, Margaret ; Rao, Santosh ; Dessoffy, Raymond ; Chen, Ji Feng ; Zhou, Qun ; Calabro, Anthony ; Banbury, Michael ; Fukamachi, Kiyotaka. / Mitral annular remodeling to treat functional mitral regurgitation : A pilot acute study in a canine model. :: Heart Surgery Forum. 2010 ; 巻 13, 番号 4.
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AU - Saraiva, Roberto M.

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AU - Park, Margaret

AU - Rao, Santosh

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AU - Chen, Ji Feng

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AU - Banbury, Michael

AU - Fukamachi, Kiyotaka

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