Mitral annular remodeling to treat functional mitral regurgitation: A pilot acute study in a canine model

Hideyuki Fumoto, Tohru Takaseya, Akira Shiose, Roberto M. Saraiva, Yoko Arakawa, Margaret Park, Santosh Rao, Raymond Dessoffy, Ji Feng Chen, Qun Zhou, Anthony Calabro, Michael Banbury, Kiyotaka Fukamachi

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

Background: The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR). Methods: Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection. Results: The injection improved MR grade from 3.4 ± 0.8 to 1.3 ± 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 ± 0.4 cm to 2.9 ± 0.3 cm; P = .039) and MR volume (20.6 ± 7.3 mm3 to 5.2 ± 2.2 mm3; P = .044). Conclusions: A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model.

本文言語英語
ページ(範囲)E247-E250
ジャーナルHeart Surgery Forum
13
4
DOI
出版ステータス出版済み - 8 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 外科
  • 循環器および心血管医学

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