Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution

Shin Ya Tosaki; Keiichi Hara; Vijay Gnanadesikan; Hiroyuki Morimoto; Shinji Harada; Mari Sugita; Noriyuki Yamagiwa; Shigeki Matsunaga; Masakatsu Shibasaki

doi:10.1021/ja064858l

Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution

Shin Ya Tosaki, Keiichi Hara, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga, Masakatsu Shibasaki

研究成果: ジャーナルへの寄稿 › 記事

92 引用（Scopus）

抜粋

A kinetic resolution of tertiary nitroaldols derived from simple ketones is described. Mixed BINOL/biphenol La-Li heterobimetallic complexes gave the best selectivity in retro-nitroaldol reactions of racemic tertiary nitroaldols. By using a mixture of La-Li₃-(1a)₃ complex (LLB 2a) and La-Li₃-(1b)₃ (LLB* 2b) complex in a ratio of 2/1, chiral tertiary nitroaldols were obtained in 80-97% ee and 30-47% recovery yield.

元の言語	英語
ページ（範囲）	11776-11777
ページ数	2
ジャーナル	Journal of the American Chemical Society
巻	128
発行部数	36
DOI	https://doi.org/10.1021/ja064858l
出版物ステータス	出版済み - 9 13 2006
外部発表	Yes

フィンガープリント

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

これを引用

Tosaki, S. Y., Hara, K., Gnanadesikan, V., Morimoto, H., Harada, S., Sugita, M., ... Shibasaki, M. (2006). Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution. Journal of the American Chemical Society, 128(36), 11776-11777. https://doi.org/10.1021/ja064858l

Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution. / Tosaki, Shin Ya; Hara, Keiichi; Gnanadesikan, Vijay; Morimoto, Hiroyuki; Harada, Shinji; Sugita, Mari; Yamagiwa, Noriyuki; Matsunaga, Shigeki; Shibasaki, Masakatsu.

：: Journal of the American Chemical Society, 巻 128, 番号 36, 13.09.2006, p. 11776-11777.

研究成果: ジャーナルへの寄稿 › 記事

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abstract = "A kinetic resolution of tertiary nitroaldols derived from simple ketones is described. Mixed BINOL/biphenol La-Li heterobimetallic complexes gave the best selectivity in retro-nitroaldol reactions of racemic tertiary nitroaldols. By using a mixture of La-Li3-(1a)3 complex (LLB 2a) and La-Li3-(1b)3 (LLB* 2b) complex in a ratio of 2/1, chiral tertiary nitroaldols were obtained in 80-97{\%} ee and 30-47{\%} recovery yield.",

author = "Tosaki, {Shin Ya} and Keiichi Hara and Vijay Gnanadesikan and Hiroyuki Morimoto and Shinji Harada and Mari Sugita and Noriyuki Yamagiwa and Shigeki Matsunaga and Masakatsu Shibasaki",

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T1 - Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution

AU - Tosaki, Shin Ya

AU - Hara, Keiichi

AU - Gnanadesikan, Vijay

AU - Morimoto, Hiroyuki

AU - Harada, Shinji

AU - Sugita, Mari

AU - Yamagiwa, Noriyuki

AU - Matsunaga, Shigeki

AU - Shibasaki, Masakatsu

PY - 2006/9/13

Y1 - 2006/9/13

N2 - A kinetic resolution of tertiary nitroaldols derived from simple ketones is described. Mixed BINOL/biphenol La-Li heterobimetallic complexes gave the best selectivity in retro-nitroaldol reactions of racemic tertiary nitroaldols. By using a mixture of La-Li3-(1a)3 complex (LLB 2a) and La-Li3-(1b)3 (LLB* 2b) complex in a ratio of 2/1, chiral tertiary nitroaldols were obtained in 80-97% ee and 30-47% recovery yield.

AB - A kinetic resolution of tertiary nitroaldols derived from simple ketones is described. Mixed BINOL/biphenol La-Li heterobimetallic complexes gave the best selectivity in retro-nitroaldol reactions of racemic tertiary nitroaldols. By using a mixture of La-Li3-(1a)3 complex (LLB 2a) and La-Li3-(1b)3 (LLB* 2b) complex in a ratio of 2/1, chiral tertiary nitroaldols were obtained in 80-97% ee and 30-47% recovery yield.

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文献にアクセス

10.1021/ja064858l