抄録
Fewer than 1 % of gastrointestinal stromal tumors (GISTs) are of the esophagus. This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge submucosal tumor in the lower thoracic and abdominal esophagus. Pathologic examination of an endoscopic biopsy sample suggested squamous cell carcinoma. She underwent subtotal esophagectomy and reconstruction with a gastric tube. Postoperative pathological diagnosis revealed a mixed spindle/epithelioid cell type GIST. The tumor measured 8 × 6 cm, with 30–50 mitotic counts per high power field, immunohistochemical positivity for C-kit (CD117) and CD34 and high risk by modified Fletcher classification. Adjuvant chemotherapy with imatinib mesylate was started 3 months after surgery. Preoperative pathological examination, including staining for CD117 and CD34, of biopsy samples of apparently stromal tumors may be required to rule out rare subtypes of GIST.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 301-305 |
| ページ数 | 5 |
| ジャーナル | Esophagus |
| 巻 | 13 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | 出版済み - 7 1 2016 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
これを引用
Mixed spindle and epithelioid cell type gastrointestinal stromal tumor of the esophagus : a case report. / Korehisa, Shotaro; Saeki, Hiroshi; Nakashima, Yuichiro; Nakaji, Yu; Tsutsumi, Satoshi; Yukaya, Takafumi; Tajiri, Hirotada; Kasagi, Yuta; Sonoda, Hideto; Sugiyama, Masahiko; Ohgaki, Kippei; Oki, Eiji; Hirahashi, Minako; Yamamoto, Hidetaka; Maehara, Yoshihiko.
：: Esophagus, 巻 13, 番号 3, 01.07.2016, p. 301-305.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Mixed spindle and epithelioid cell type gastrointestinal stromal tumor of the esophagus
T2 - a case report
AU - Korehisa, Shotaro
AU - Saeki, Hiroshi
AU - Nakashima, Yuichiro
AU - Nakaji, Yu
AU - Tsutsumi, Satoshi
AU - Yukaya, Takafumi
AU - Tajiri, Hirotada
AU - Kasagi, Yuta
AU - Sonoda, Hideto
AU - Sugiyama, Masahiko
AU - Ohgaki, Kippei
AU - Oki, Eiji
AU - Hirahashi, Minako
AU - Yamamoto, Hidetaka
AU - Maehara, Yoshihiko
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Fewer than 1 % of gastrointestinal stromal tumors (GISTs) are of the esophagus. This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge submucosal tumor in the lower thoracic and abdominal esophagus. Pathologic examination of an endoscopic biopsy sample suggested squamous cell carcinoma. She underwent subtotal esophagectomy and reconstruction with a gastric tube. Postoperative pathological diagnosis revealed a mixed spindle/epithelioid cell type GIST. The tumor measured 8 × 6 cm, with 30–50 mitotic counts per high power field, immunohistochemical positivity for C-kit (CD117) and CD34 and high risk by modified Fletcher classification. Adjuvant chemotherapy with imatinib mesylate was started 3 months after surgery. Preoperative pathological examination, including staining for CD117 and CD34, of biopsy samples of apparently stromal tumors may be required to rule out rare subtypes of GIST.
AB - Fewer than 1 % of gastrointestinal stromal tumors (GISTs) are of the esophagus. This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge submucosal tumor in the lower thoracic and abdominal esophagus. Pathologic examination of an endoscopic biopsy sample suggested squamous cell carcinoma. She underwent subtotal esophagectomy and reconstruction with a gastric tube. Postoperative pathological diagnosis revealed a mixed spindle/epithelioid cell type GIST. The tumor measured 8 × 6 cm, with 30–50 mitotic counts per high power field, immunohistochemical positivity for C-kit (CD117) and CD34 and high risk by modified Fletcher classification. Adjuvant chemotherapy with imatinib mesylate was started 3 months after surgery. Preoperative pathological examination, including staining for CD117 and CD34, of biopsy samples of apparently stromal tumors may be required to rule out rare subtypes of GIST.
UR - http://www.scopus.com/inward/record.url?scp=84961989827&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961989827&partnerID=8YFLogxK
U2 - 10.1007/s10388-016-0525-9
DO - 10.1007/s10388-016-0525-9
M3 - Article
AN - SCOPUS:84961989827
VL - 13
SP - 301
EP - 305
JO - Esophagus
JF - Esophagus
SN - 1612-9059
IS - 3
ER -