Modeling Lung Branching Morphogenesis

研究成果: Chapter in Book/Report/Conference proceedingChapter

27 被引用数 (Scopus)

抄録

Vertebrate lung has tree-like structure which facilitates gas exchange. After discovery of the involvement of several key toolkit genes-FGF10, BMP4, and Shh, huge amount of molecular information on lung development is now available. However, how their interactions result in a branched structure has not been elucidated. Recently, some studies have utilized mathematical models to understand the mechanism of branching morphogenesis, and we now have some models which are reliable enough to make experimental predictions in the in vitro system. In addition, a different type of modeling, which generates tree-like branching pattern by repeatedly applying a set of simple rules iteratively, is also utilized to model lung function. In this review, I focus on how these models can contribute to understand pattern formation phenomena from experimental biologist's point of view.

本文言語英語
ホスト出版物のタイトルMultiscale Modeling of Developmental Systems
編集者Santiago Schnell, Philip Maini, Stuart Newman, Timothy Newman
ページ291-310
ページ数20
DOI
出版ステータス出版済み - 1 1 2008
外部発表はい

出版物シリーズ

名前Current Topics in Developmental Biology
81
ISSN(印刷版)0070-2153

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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