Modelling of articular cartilage containing chondrocytes and finite element analysis for articular cartilage and chondrocytes under compression

Maki Ihara, Teruo Murakami, Yoshinori Sawae

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

It is well accepted that articular cartilage adapts to changing mechanical environments. As the rubbing condition is getting severe, the articular cartilage will be worn, resulting in osteoarthritis. but little is known about the mechanism to osteoarthritis. It is important to clear the stress-strain state of cartilage and in chondrocytes under repeated cartilage deformation to know how osteoarthritis gets to start and progress. The purpose of this study is to investigate an influence of chondrocytes on stress-strain state of articular cartilage and an influence of position of chondrocyte on its depth-dependent deformation. FEM analyses predict time-dependent stress-strain state of articular cartilage because of fluid exudation, but material properties of chondrocytes do not affect the behavior of articular cartilage so much. The deformation of chondrocyte is depth-dependent and the largest time-dependent deformation behavior occurs in the surface layer. These results may clear how the transduction of mechanical stimuli concern about metabolism of articular cartilage via chondrocytes.

本文言語英語
ページ(範囲)487-493
ページ数7
ジャーナルNippon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A
69
2
DOI
出版ステータス出版済み - 2 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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