Modulation of group I ribozyme activity by cationic porphyrins

Shigeyoshi Matsumura, Tatsunobu Ito, Takahiro Tanaka, Hiroyuki Furuta, Yoshiya Ikawa

    研究成果: ジャーナルへの寄稿学術誌査読

    3 被引用数 (Scopus)

    抄録

    The effects of cationic porphyrins on the catalytic activities of four group I ribozymes were investigated. A cationic porphyrin possessing four pyridinium moieties (pPyP) inhibited two group IC3 ribozymes (Syn Rz and Azo Rz) and a group IC1 ribozyme (Tet Rz). In the case of a group IA2 ribozyme (Td Rz), however, pPyP served not only as an inhibitor but also as an activator, and the effects of pPyP were dependent on its concentration. To analyze the structural and electronic factors determining the effects of pPyP on group I ribozymes, three cationic porphyrins (pPyNCP, pPyF4P, and TMPyP) were also examined. As interactions between small organic molecules and nucleic acids are attractive and important issues in biochemistry and biotechnology, this study contributes to the development of porphyrin-based molecules that can modulate functions of structured RNA molecules.

    本文言語英語
    ページ(範囲)251-263
    ページ数13
    ジャーナルBiology
    4
    2
    DOI
    出版ステータス出版済み - 3月 24 2015

    !!!All Science Journal Classification (ASJC) codes

    • 生化学、遺伝学、分子生物学(全般)
    • 免疫学および微生物学(全般)
    • 農業および生物科学(全般)

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