Modulation of sweet responses of taste receptor cells

Ryusuke Yoshida, Mayu Niki, Masafumi Jyotaki, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

研究成果: ジャーナルへの寄稿評論記事

24 引用 (Scopus)

抄録

Taste receptor cells play a major role in detection of chemical compounds in the oral cavity. Information derived from taste receptor cells, such as sweet, bitter, salty, sour and umami is important for evaluating the quality of food components. Among five basic taste qualities, sweet taste is very attractive for animals and influences food intake. Recent studies have demonstrated that sweet taste sensitivity in taste receptor cells would be affected by leptin and endocannabinoids. Leptin is an anorexigenic mediator that reduces food intake by acting on leptin receptor Ob-Rb in the hypothalamus. Endocannabinoids such as anandamide [N-arachidonoylethanolamine (AEA)] and 2-arachidonoyl glycerol (2-AG) are known as orexigenic mediators that act via cannabinoid receptor 1 (CB1) in the hypothalamus and limbic forebrain to induce appetite and stimulate food intake. At the peripheral gustatory organs, leptin selectively suppresses and endocannabinoids selectively enhance sweet taste sensitivity via Ob-Rb and CB1 expressed in sweet sensitive taste cells. Thus leptin and endocannabinoids not only regulate food intake via central nervous systems but also modulate palatability of foods by altering peripheral sweet taste responses. Such reciprocal modulation of leptin and endocannabinoids on peripheral sweet sensitivity may play an important role in regulating energy homeostasis.

元の言語英語
ページ(範囲)226-231
ページ数6
ジャーナルSeminars in Cell and Developmental Biology
24
発行部数3
DOI
出版物ステータス出版済み - 1 1 2013

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Endocannabinoids
Leptin
Eating
Cannabinoid Receptors
Hypothalamus
Leptin Receptors
Food Quality
Appetite
Prosencephalon
Mouth
Homeostasis
Central Nervous System
Food

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

これを引用

Modulation of sweet responses of taste receptor cells. / Yoshida, Ryusuke; Niki, Mayu; Jyotaki, Masafumi; Sanematsu, Keisuke; Shigemura, Noriatsu; Ninomiya, Yuzo.

:: Seminars in Cell and Developmental Biology, 巻 24, 番号 3, 01.01.2013, p. 226-231.

研究成果: ジャーナルへの寄稿評論記事

Yoshida, Ryusuke ; Niki, Mayu ; Jyotaki, Masafumi ; Sanematsu, Keisuke ; Shigemura, Noriatsu ; Ninomiya, Yuzo. / Modulation of sweet responses of taste receptor cells. :: Seminars in Cell and Developmental Biology. 2013 ; 巻 24, 番号 3. pp. 226-231.
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