Modulation of UDP-glucuronosyltransferase activity by protein-protein association

Yuji Ishii, Shuso Takeda, Hideyuki Yamada

研究成果: ジャーナルへの寄稿総説査読

43 被引用数 (Scopus)

抄録

Drug oxidation and conjugation mediated by cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) have long been considered to take place separately. However, our recent studies have suggested that CYP3A4 specifically associates with UGT2B7 and alters the regioselectivity of morphine glucuronidation. This observation strongly supports the view that there is functional cooperation between P450 and UGT to facilitate multistep drug metabolism. In recent years, accumulating evidence has suggested an interaction between UGT isoforms or between P450 and UGTs and a change in UGT function by protein-protein association. In this review, we summarize these interactions and discuss their relevance to UGT function.

本文言語英語
ページ(範囲)145-158
ページ数14
ジャーナルDrug Metabolism Reviews
42
1
DOI
出版ステータス出版済み - 2月 2010

!!!All Science Journal Classification (ASJC) codes

  • 薬理学、毒性学および薬学(全般)
  • 薬理学(医学)

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