Modulators of voltage-dependent calcium channels for the treatment of nervous system diseases

Eiki Takahashi, Kimie Niimi

研究成果: Contribution to journalReview article査読

7 被引用数 (Scopus)

抄録

Voltage-dependent Ca2+ channels (VDCCs) play important roles in physiological functions and pathological processes of the nervous system. Given that the precise regulation of Ca2+ signaling is important for neuronal processes such as action potential generation, transmitter release, and synaptic plasticity, alterations in Ca2+ current through VDCCs affect the functions of neurons and circuits. Central nervous system (CNS) diseases, including pain, epilepsy, seizure, anxiety, depression, dementia, and stroke, are characterized by an altered balance between excitatory and inhibitory neuronal functions. An efficient way of controlling such diseases is to block or modulate VDCC function. An effective strategy to reduce the likelihood of adverse effects is to develop agents that selectively control the VDCC isoform/subunit involved in the mechanism of the disease in question. This review provides an overview of knowledge on VDCCs, traditional and newly developed therapeutic fields, clinical fields, and the diverse medicinal chemistry of traditional and newly developed VDCC blockers in the CNS based on the scientific and patent literature.

本文言語英語
ページ(範囲)96-111
ページ数16
ジャーナルRecent Patents on CNS Drug Discovery
4
2
DOI
出版ステータス出版済み - 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 創薬
  • 精神医学および精神衛生
  • 薬理学(医学)

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