Molecular and functional diversity of fungal cytochrome P450s

研究成果: ジャーナルへの寄稿評論記事

20 引用 (Scopus)

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A series of genome projects have uncovered an astonishing molecular diversity of cytochrome P450s in the fungal kingdom. Fungal P450s discovered from such projects are often categorized into novel families and subfamilies. It thus appears that the divergence of fungal P450s is greater than of animal, plant, or bacterial P450s. The tremendous variation implies that fungi have vigorously diversified P450 functions to meet novel metabolic needs. To better understand the metabolic diversity of fungi, one must undertake the challenging task of exploiting the catalytic functions of numerous P450s. A compilation of P450 functions will also enable us to utilize their catalytic potentials in biotechnology. Experimental screening remains essential however, to elucidate the catalytic potentials of individual P450s. This review outlines the molecular and genomic aspects of fungal P450s, and introduces new functions revealed by functionomic studies using a recently developed, rapid, functional screening system.

元の言語英語
ページ(範囲)833-837
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
35
発行部数6
DOI
出版物ステータス出版済み - 1 1 2012

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Cytochromes
Fungi
Biotechnology
Genome

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

これを引用

Molecular and functional diversity of fungal cytochrome P450s. / Ichinose, Hirofumi.

:: Biological and Pharmaceutical Bulletin, 巻 35, 番号 6, 01.01.2012, p. 833-837.

研究成果: ジャーナルへの寄稿評論記事

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