Molecular basis for cancer chemoprevention by green tea polyphenol EGCG

研究成果: Chapter in Book/Report/Conference proceedingChapter

68 被引用数 (Scopus)

抄録

For the past two decades, many researchers have been investigating the potential cancer-preventive and therapeutic effects of green tea. (-)-Epigallocatechin-3-O-gallate (EGCG) has been shown to be the most active and major polyphenolic compound from green tea. The mechanisms of action of EGCG have been extensively investigated. However, the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently, we have identified the 67-kDa laminin receptor (67LR) as a cell surface EGCG receptor that confers EGCG responsiveness to many cancer cells at physiological concentrations. This article reviews some of the reported mechanisms and possible targets for the action of EGCG. We especially focus on the current understanding of the signaling pathway for physiologically relevant EGCG through the 67LR for cancer prevention. Our data shed new light on the molecular basis for the cancer-preventive activity of EGCG in vivo and helps in the design of new strategies to prevent cancer.

本文言語英語
ホスト出版物のタイトルFood Factors for Health Promotion
編集者Toshikazu Yoshikawa
ページ156-169
ページ数14
DOI
出版ステータス出版済み - 7 31 2009

出版物シリーズ

名前Forum of Nutrition
61
ISSN(印刷版)1660-0347

All Science Journal Classification (ASJC) codes

  • 栄養および糖尿病
  • 公衆衛生学、環境および労働衛生

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