Molecular basis for pre-TCR-mediated autonomous signaling

Shou Yamasaki, Takashi Saito

    研究成果: ジャーナルへの寄稿総説査読

    53 被引用数 (Scopus)

    抄録

    The pre-T-cell receptor (pre-TCR) is a multimeric complex composed of a nascent TCRβ chain, an invariant pre-TCRα (pTα) chain and CD3 molecules, and is crucial for early T-cell development. Despite its structural similarity to the mature αβTCR, which requires MHC-antigen for receptor triggering, the pre-TCR is proposed to initiate signals in a ligand-independent manner. However, the molecular mechanism underlying the autonomous signaling is still unclear. Recent studies have revealed that pTα possesses unique characteristics that promote autonomous signaling. In this review, we summarize current data relating to the molecular mechanism underlying the initiation of pre-TCR-mediated autonomous signaling.

    本文言語英語
    ページ(範囲)39-43
    ページ数5
    ジャーナルTrends in Immunology
    28
    1
    DOI
    出版ステータス出版済み - 1月 1 2007

    !!!All Science Journal Classification (ASJC) codes

    • 免疫アレルギー学
    • 免疫学

    フィンガープリント

    「Molecular basis for pre-TCR-mediated autonomous signaling」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル