Molecular basis for the anti-cancer activity of egcg in vivo: Molecular-targeting prevention of cancer by green tea catechin

Yoshinori Fujimura, Hirofumi Tachibana

研究成果: 著書/レポートタイプへの貢献

抄録

For the past two decades, many researchers have been investigated the potential cancer-preventive and therapeutic effects of green tea. (-)-Epigallocatechin-3-O-gallate (EGCG) has been shown to be the most active and major polyphenolic compound from green tea. The mechanisms of action of EGCG have been extensively investigated, but the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently we have identified 67-kDa laminin receptor (67LR) as a cell-surface EGCG receptor that confers EGCG responsiveness to many cancer cells at physiological concentrations. This article reviews some of the reported mechanisms and possible targets for the action of EGCG. Especially, we focus the current understanding of signaling pathway for physiologically relevant EGCG through the 67LR for cancer prevention. This information shed new light on the molecular basis for the cancer-preventive activity of EGCG in vivo and helps in the design of new strategies to prevent cancer.

元の言語英語
ホスト出版物のタイトルHandbook of Green Tea and Health Research
出版者Nova Science Publishers, Inc.
ページ257-299
ページ数43
ISBN(印刷物)9781607410454
出版物ステータス出版済み - 2 1 2009

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Catechin
Tea
Neoplasms
Laminin Receptors
epigallocatechin gallate
Therapeutic Uses
Research Personnel

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Fujimura, Y., & Tachibana, H. (2009). Molecular basis for the anti-cancer activity of egcg in vivo: Molecular-targeting prevention of cancer by green tea catechin. : Handbook of Green Tea and Health Research (pp. 257-299). Nova Science Publishers, Inc..

Molecular basis for the anti-cancer activity of egcg in vivo : Molecular-targeting prevention of cancer by green tea catechin. / Fujimura, Yoshinori; Tachibana, Hirofumi.

Handbook of Green Tea and Health Research. Nova Science Publishers, Inc., 2009. p. 257-299.

研究成果: 著書/レポートタイプへの貢献

Fujimura, Y & Tachibana, H 2009, Molecular basis for the anti-cancer activity of egcg in vivo: Molecular-targeting prevention of cancer by green tea catechin. : Handbook of Green Tea and Health Research. Nova Science Publishers, Inc., pp. 257-299.
Fujimura Y, Tachibana H. Molecular basis for the anti-cancer activity of egcg in vivo: Molecular-targeting prevention of cancer by green tea catechin. : Handbook of Green Tea and Health Research. Nova Science Publishers, Inc. 2009. p. 257-299
Fujimura, Yoshinori ; Tachibana, Hirofumi. / Molecular basis for the anti-cancer activity of egcg in vivo : Molecular-targeting prevention of cancer by green tea catechin. Handbook of Green Tea and Health Research. Nova Science Publishers, Inc., 2009. pp. 257-299
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