Molecular cloning and characterization of a putative cyclic nucleotide-gated channel from Drosophila melanogaster

M. Miyazu, T. Tanimura, Masahiro Sokabe

研究成果: ジャーナルへの寄稿学術誌査読

21 被引用数 (Scopus)

抄録

We have cloned a cDNA encoding a putative cyclic nucleotide-gated (CNG) channel from Drosophila melanogaster. The N-terminal half of the predicted protein, designated as CNGL, shows a high degree of sequence similarity with the known CNG channel proteins. CNGL has a long hydrophilic C-terminal stretch that is absent in other CNG channels. Northern blot analysis revealed that the messenger RNA (mRNA) corresponding to the size of the cloned cDNA is expressed in Drosophila heads. Immunolocalization studies showed that CNGL is expressed in the brain, including the medulla, Iobulla and Iobulla plate, the antennal lobe glomeruli, and mushroom bodies. These results suggest a possible role of the putative CNGL channel in the processing of visual and olfactory information in the nervous system of Drosophila.

本文言語英語
ページ(範囲)283-292
ページ数10
ジャーナルInsect Molecular Biology
9
3
DOI
出版ステータス出版済み - 6月 1 2000

!!!All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 遺伝学
  • 昆虫科学

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