Molecular cloning and identification of two types of hamster cyclin-dependent kinases: CDK2 and CDK2L

Eishi Noguchi, Takeshi Sekiguchi, Katsumi Yamashita, Takeharu Nishimoto

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

We isolated two types of hamster cyclin-dependent kinase 2 (cdk2) cDNAs from BHK21 cells derived from Golden hamsters. One type of cdk2 (cdk2hm) encodes the 32 kDa protein consisting of 298 predicted amino acids and shows strong homology to the cdk2 cDNAs of humans and Xenopus. The other cdk2 (cdk2Lhm) encodes the 38 kDa protein containing the insertion of 48 amino acids in the cdk2hm protein. Immunoblotting analysis suggested that these two types of cdk2 protein exist in mammalian cells. The cdk2hm has the activity of protein kinase, while the cdk2Lhm does not, however, both bind with cyclin E.

本文言語英語
ページ(範囲)1524-1529
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
197
3
DOI
出版ステータス出版済み - 12 30 1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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