Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex

Michiyo Imai, Hideo Shimada, Yukiko Okada, Yuko Matsushima-Hibiya, Tadashi Ogishima, Yuzuru Ishimura

研究成果: Contribution to journalArticle査読

88 被引用数 (Scopus)

抄録

Using an oligonucleotide probe designed on the basis of the N-terminal amino acid sequence of purified rat aldosterone synthase cytochrome P-450 [(1989) J. Biol. Chem. 264 10935] we have isolated from rat adrenal cDNA library a 2687 base pair cDNA that encodes a protein of 500 amino acid residues. The deduced amino acid sequence contained the regions well conserved among all cytochrome P-450s sequenced to date, and also a portion (residues 25-44) which was identical to the N-terminal peptide sequence of rat aldosterone synthase cytochrome P-450. These results indicate that the cDNA encodes a precursor form of rat aldosterone synthase cytochrome P-450.

本文言語英語
ページ(範囲)299-302
ページ数4
ジャーナルFEBS Letters
263
2
DOI
出版ステータス出版済み - 4 24 1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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