Molecular composition and regulation of the Nox family NAD(P)H oxidases

Hideki Sumimoto, Kei Miyano, Ryu Takeya

研究成果: ジャーナルへの寄稿評論記事

225 引用 (Scopus)

抄録

Reactive oxygen species (ROS) are conventionally regarded as inevitable deleterious by-products in aerobic metabolism with a few exceptions such as their significant role in host defense. The phagocyte NADPH oxidase, dormant in resting cells, becomes activated during phagocytosis to deliberately produce superoxide, a precursor of other microbicidal ROS, thereby playing a crucial role in killing pathogens. The catalytic center of this oxidase is the membrane-integrated protein gp91phox, tightly complexed with p22 phox, and its activation requires the association with p47 phox, p67phox, and the small GTPase Rac, which normally reside in the cytoplasm. Since recent discovery of non-phagocytic gp91 phox-related enzymes of the NAD(P)H oxidase (Nox) family-seven homologues identified in humans-deliberate ROS production has been increasingly recognized as important components of various cellular events. Here, we describe a current view on the molecular composition and post-translational regulation of Nox-family oxidases in animals.

元の言語英語
ページ(範囲)677-686
ページ数10
ジャーナルBiochemical and Biophysical Research Communications
338
発行部数1
DOI
出版物ステータス出版済み - 12 9 2005

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NADPH Oxidase
Reactive Oxygen Species
Oxidoreductases
Chemical analysis
Monomeric GTP-Binding Proteins
Pathogens
Phagocytes
Phagocytosis
Metabolism
Superoxides
Byproducts
Membrane Proteins
Cytoplasm
Animals
Chemical activation
Association reactions
Enzymes
4-ethoxymethylene-2-phenyl-2-oxazoline-5-one

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Molecular composition and regulation of the Nox family NAD(P)H oxidases. / Sumimoto, Hideki; Miyano, Kei; Takeya, Ryu.

:: Biochemical and Biophysical Research Communications, 巻 338, 番号 1, 09.12.2005, p. 677-686.

研究成果: ジャーナルへの寄稿評論記事

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AB - Reactive oxygen species (ROS) are conventionally regarded as inevitable deleterious by-products in aerobic metabolism with a few exceptions such as their significant role in host defense. The phagocyte NADPH oxidase, dormant in resting cells, becomes activated during phagocytosis to deliberately produce superoxide, a precursor of other microbicidal ROS, thereby playing a crucial role in killing pathogens. The catalytic center of this oxidase is the membrane-integrated protein gp91phox, tightly complexed with p22 phox, and its activation requires the association with p47 phox, p67phox, and the small GTPase Rac, which normally reside in the cytoplasm. Since recent discovery of non-phagocytic gp91 phox-related enzymes of the NAD(P)H oxidase (Nox) family-seven homologues identified in humans-deliberate ROS production has been increasingly recognized as important components of various cellular events. Here, we describe a current view on the molecular composition and post-translational regulation of Nox-family oxidases in animals.

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