Molecular evolution of amphioxus fructose-1,6 bisphosphate aldolase

Masako Kuba, Hitomi Yatsuki, Takahiro Kusakabe, Yozo Takasaki, Naruo Nikoh, Takashi Miyata, Takao Yamaguchi, Katsuji Hori

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

The cDNA for amphioxus fructose-1,6-bisphosphate (FBP)-aldolase was isolated and its nucleotide sequence was determined. In the cDNA, there existed a probable open reading frame comprising 1080 bp; hence, 359 amino acid residues were deduced. The amino acid sequence indicates the deletion of 4 residues from N-terminus, in comparison with the sequence of FBP-aldolase isozymes from other sources. There was only one FBP-aldolase gene, and one enzyme species corresponding, in the amphioxus; this is the first report of the existence of a single FBP-aldolase species in animals. Enzymatic studies of both native and the recombinant FBP-aldolase suggest that the amphioxus enzyme belongs to an ancestral class I type which is not discovered among vertebrate aldolase isozymes.

本文言語英語
ページ(範囲)329-336
ページ数8
ジャーナルArchives of Biochemistry and Biophysics
348
2
DOI
出版ステータス出版済み - 12 15 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学

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