Molecular mechanism for chromatin regulation during MCM loading in mammalian cells

研究成果: 著書/レポートタイプへの貢献

2 引用 (Scopus)

抄録

DNA replication is a fundamental process required for the accurate and timely duplication of chromosomes. During late mitosis to G1 phase, the MCM2-7 complex is loaded onto chromatin in a manner dependent on ORC, CDC6, and Cdt1, and chromatin becomes licensed for replication. Although every eukaryotic organism shares common features in replication control, there are also some differences among species. For example, in higher eukaryotic cells including human cells, no strict sequence specificity has been observed for replication origins, unlike budding yeast or bacterial replication origins. Therefore, elements other than beyond DNA sequences are important for regulating replication. For example, the stability and precise positioning of nucleosomes affects replication control. However, little is known about how nucleosome structure is regulated when replication licensing occurs. During the last decade, histone acetylation enzyme HBO1, chromatin remodeler SNF2H, and histone chaperone GRWD1 have been identified as chromatin-handling factors involved in the promotion of replication licensing. In this review, we discuss how the rearrangement of nucleosome formation by these factors affects replication licensing.

元の言語英語
ホスト出版物のタイトルAdvances in Experimental Medicine and Biology
出版者Springer New York LLC
ページ61-78
ページ数18
DOI
出版物ステータス出版済み - 1 1 2017

出版物シリーズ

名前Advances in Experimental Medicine and Biology
1042
ISSN(印刷物)0065-2598
ISSN(電子版)2214-8019

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Multicarrier modulation
Chromatin
Nucleosomes
Licensure
Cells
Replication Origin
Minichromosome Maintenance Proteins
Histone Chaperones
Chromosome Duplication
Acetylation
Saccharomycetales
DNA sequences
G1 Phase
Eukaryotic Cells
Chromosomes
DNA Replication
Mitosis
Histones
Yeast
DNA

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Sugimoto, N., & Fujita, M. (2017). Molecular mechanism for chromatin regulation during MCM loading in mammalian cells. : Advances in Experimental Medicine and Biology (pp. 61-78). (Advances in Experimental Medicine and Biology; 巻数 1042). Springer New York LLC. https://doi.org/10.1007/978-981-10-6955-0_3

Molecular mechanism for chromatin regulation during MCM loading in mammalian cells. / Sugimoto, Nozomi; Fujita, Masatoshi.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2017. p. 61-78 (Advances in Experimental Medicine and Biology; 巻 1042).

研究成果: 著書/レポートタイプへの貢献

Sugimoto, N & Fujita, M 2017, Molecular mechanism for chromatin regulation during MCM loading in mammalian cells. : Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, 巻. 1042, Springer New York LLC, pp. 61-78. https://doi.org/10.1007/978-981-10-6955-0_3
Sugimoto N, Fujita M. Molecular mechanism for chromatin regulation during MCM loading in mammalian cells. : Advances in Experimental Medicine and Biology. Springer New York LLC. 2017. p. 61-78. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-981-10-6955-0_3
Sugimoto, Nozomi ; Fujita, Masatoshi. / Molecular mechanism for chromatin regulation during MCM loading in mammalian cells. Advances in Experimental Medicine and Biology. Springer New York LLC, 2017. pp. 61-78 (Advances in Experimental Medicine and Biology).
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