Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion

Yutaka Matsui, Shiori Kyoi, Hiromitsu Takagi, Chiao Po Hsu, Nirmala Hariharan, Tetsuro Ago, Stephen F. Vatner, Junichi Sadoshima

研究成果: ジャーナルへの寄稿評論記事

135 引用 (Scopus)

抄録

Autophagy is an intracellular bulk degradation process whereby cytoplasmic proteins and organelles are degraded and recycled through lysosomes. In the heart, autophagy plays a homeostatic role at basal levels, and the absence of autophagy causes cardiac dysfunction and the development of cardiomyopathy. Autophagy is induced during myocardial ischemia and further enhanced by reperfusion. Although induction of autophagy during the ischemic phase is protective, further enhancement of autophagy during the reperfusion phase may induce cell death and appears to be detrimental. In this review we discuss the functional significance of autophagy and the underlying signaling mechanism in the heart during ischemia/reperfusion.

元の言語英語
ページ(範囲)409-415
ページ数7
ジャーナルAutophagy
4
発行部数4
DOI
出版物ステータス出版済み - 5 16 2008

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Myocardial Reperfusion
Autophagy
Myocardial Ischemia
Reperfusion
Lysosomes
Cardiomyopathies
Organelles
Cell Death
Ischemia

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

これを引用

Matsui, Y., Kyoi, S., Takagi, H., Hsu, C. P., Hariharan, N., Ago, T., ... Sadoshima, J. (2008). Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy, 4(4), 409-415. https://doi.org/10.4161/auto.5638

Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. / Matsui, Yutaka; Kyoi, Shiori; Takagi, Hiromitsu; Hsu, Chiao Po; Hariharan, Nirmala; Ago, Tetsuro; Vatner, Stephen F.; Sadoshima, Junichi.

:: Autophagy, 巻 4, 番号 4, 16.05.2008, p. 409-415.

研究成果: ジャーナルへの寄稿評論記事

Matsui, Y, Kyoi, S, Takagi, H, Hsu, CP, Hariharan, N, Ago, T, Vatner, SF & Sadoshima, J 2008, 'Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion', Autophagy, 巻. 4, 番号 4, pp. 409-415. https://doi.org/10.4161/auto.5638
Matsui, Yutaka ; Kyoi, Shiori ; Takagi, Hiromitsu ; Hsu, Chiao Po ; Hariharan, Nirmala ; Ago, Tetsuro ; Vatner, Stephen F. ; Sadoshima, Junichi. / Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. :: Autophagy. 2008 ; 巻 4, 番号 4. pp. 409-415.
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AU - Ago, Tetsuro

AU - Vatner, Stephen F.

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