[Molecular pathology of multiple sclerosis and neuromyelitis optica]

研究成果: Contribution to journalArticle査読

抄録

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory demyelinating diseases of the central nervous system (CNS). The pathological hallmark of MS is sharply demarcated demyelinating plaques with the relative preservation of axons, suggesting autoimmune responses target CNS myelin. In contrast, NMO shows selective and severe attacks of both axons and myelin of the optic nerves and spinal cord, resulting in necrotic cavitation. Neuropathological studies have demonstrated extensive loss of aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) in NMO lesions, especially in perivascular areas of acute inflammatory lesions where immunoglobulins and activated complements are deposited. We recently demonstrated the extensive loss of connexins(Cxs) in active lesions of Baló's disease, MS and NMO. Early disruption of Cx gap junction among glial cells may be a common denominator in heterogeneous human demyelinating conditions. This review aims to discuss the molecular pathology of MS and NMO that have attracted the most attention in the recent years.

本文言語英語
ページ(範囲)1909-1917
ページ数9
ジャーナルNihon rinsho. Japanese journal of clinical medicine
72
11
出版ステータス出版済み - 11 1 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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