[Molecular pathology of multiple sclerosis and neuromyelitis optica]

研究成果: ジャーナルへの寄稿記事

抄録

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory demyelinating diseases of the central nervous system (CNS). The pathological hallmark of MS is sharply demarcated demyelinating plaques with the relative preservation of axons, suggesting autoimmune responses target CNS myelin. In contrast, NMO shows selective and severe attacks of both axons and myelin of the optic nerves and spinal cord, resulting in necrotic cavitation. Neuropathological studies have demonstrated extensive loss of aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) in NMO lesions, especially in perivascular areas of acute inflammatory lesions where immunoglobulins and activated complements are deposited. We recently demonstrated the extensive loss of connexins(Cxs) in active lesions of Baló's disease, MS and NMO. Early disruption of Cx gap junction among glial cells may be a common denominator in heterogeneous human demyelinating conditions. This review aims to discuss the molecular pathology of MS and NMO that have attracted the most attention in the recent years.

元の言語英語
ページ(範囲)1909-1917
ページ数9
ジャーナルNihon rinsho. Japanese journal of clinical medicine
72
発行部数11
出版物ステータス出版済み - 11 1 2014
外部発表Yes

Fingerprint

Neuromyelitis Optica
Molecular Pathology
Multiple Sclerosis
Myelin Sheath
Axons
Central Nervous System
Aquaporin 4
Connexins
Gap Junctions
Glial Fibrillary Acidic Protein
Demyelinating Diseases
Optic Nerve
Autoimmunity
Neuroglia
Immunoglobulins
Spinal Cord

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

[Molecular pathology of multiple sclerosis and neuromyelitis optica]. / Masaki, Katsuhisa.

:: Nihon rinsho. Japanese journal of clinical medicine, 巻 72, 番号 11, 01.11.2014, p. 1909-1917.

研究成果: ジャーナルへの寄稿記事

@article{f8777bf0c02d4f31b465eeb3e00945a3,
title = "[Molecular pathology of multiple sclerosis and neuromyelitis optica]",
abstract = "Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory demyelinating diseases of the central nervous system (CNS). The pathological hallmark of MS is sharply demarcated demyelinating plaques with the relative preservation of axons, suggesting autoimmune responses target CNS myelin. In contrast, NMO shows selective and severe attacks of both axons and myelin of the optic nerves and spinal cord, resulting in necrotic cavitation. Neuropathological studies have demonstrated extensive loss of aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) in NMO lesions, especially in perivascular areas of acute inflammatory lesions where immunoglobulins and activated complements are deposited. We recently demonstrated the extensive loss of connexins(Cxs) in active lesions of Bal{\'o}'s disease, MS and NMO. Early disruption of Cx gap junction among glial cells may be a common denominator in heterogeneous human demyelinating conditions. This review aims to discuss the molecular pathology of MS and NMO that have attracted the most attention in the recent years.",
author = "Katsuhisa Masaki",
year = "2014",
month = "11",
day = "1",
language = "English",
volume = "72",
pages = "1909--1917",
journal = "Astrophysical Journal",
issn = "0004-637X",
publisher = "IOP Publishing Ltd.",
number = "11",

}

TY - JOUR

T1 - [Molecular pathology of multiple sclerosis and neuromyelitis optica]

AU - Masaki, Katsuhisa

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory demyelinating diseases of the central nervous system (CNS). The pathological hallmark of MS is sharply demarcated demyelinating plaques with the relative preservation of axons, suggesting autoimmune responses target CNS myelin. In contrast, NMO shows selective and severe attacks of both axons and myelin of the optic nerves and spinal cord, resulting in necrotic cavitation. Neuropathological studies have demonstrated extensive loss of aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) in NMO lesions, especially in perivascular areas of acute inflammatory lesions where immunoglobulins and activated complements are deposited. We recently demonstrated the extensive loss of connexins(Cxs) in active lesions of Baló's disease, MS and NMO. Early disruption of Cx gap junction among glial cells may be a common denominator in heterogeneous human demyelinating conditions. This review aims to discuss the molecular pathology of MS and NMO that have attracted the most attention in the recent years.

AB - Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory demyelinating diseases of the central nervous system (CNS). The pathological hallmark of MS is sharply demarcated demyelinating plaques with the relative preservation of axons, suggesting autoimmune responses target CNS myelin. In contrast, NMO shows selective and severe attacks of both axons and myelin of the optic nerves and spinal cord, resulting in necrotic cavitation. Neuropathological studies have demonstrated extensive loss of aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) in NMO lesions, especially in perivascular areas of acute inflammatory lesions where immunoglobulins and activated complements are deposited. We recently demonstrated the extensive loss of connexins(Cxs) in active lesions of Baló's disease, MS and NMO. Early disruption of Cx gap junction among glial cells may be a common denominator in heterogeneous human demyelinating conditions. This review aims to discuss the molecular pathology of MS and NMO that have attracted the most attention in the recent years.

UR - http://www.scopus.com/inward/record.url?scp=84922324997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922324997&partnerID=8YFLogxK

M3 - Article

C2 - 25518370

AN - SCOPUS:84922324997

VL - 72

SP - 1909

EP - 1917

JO - Astrophysical Journal

JF - Astrophysical Journal

SN - 0004-637X

IS - 11

ER -