Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

研究成果: 著書/レポートタイプへの貢献

抄録

Accumulating clinical data indicates that insulin resistance and diabetes mellitus (DM) are major risk factors for Alzheimer’s disease (AD); however, the exact mechanisms on how insulin resistance and DM act as risk factors for AD remain unclear. Recent progress in gene expression profiling of AD brains revealed that brain insulin production and insulin signaling are significantly impaired, indicating that AD brain exhibits a feature of brain diabetes with depletion of brain insulin, which causes mitochondrial dysfunction with increased oxidative stress, thereby increasing sensitivity to peripheral diabetes. Such diabetic condition in early stage of AD brain can be exacerbated by peripheral diabetes, namely, through hyperglycemia, hyperinsulinemia, or impaired insulin response. In this chapter, I reviewed mitochondrial dysfunction and oxidative stress in AD brain and discussed how those events are involved in AD pathogenesis.

元の言語英語
ホスト出版物のタイトルAdvances in Experimental Medicine and Biology
出版者Springer New York LLC
ページ27-44
ページ数18
DOI
出版物ステータス出版済み - 1 1 2019

出版物シリーズ

名前Advances in Experimental Medicine and Biology
1128
ISSN(印刷物)0065-2598
ISSN(電子版)2214-8019

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Oxidative stress
Brain
Alzheimer Disease
Oxidative Stress
Medical problems
Insulin
Insulin Resistance
Diabetes Mellitus
Hyperinsulinism
Gene Expression Profiling
Gene expression
Hyperglycemia

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Nakabeppu, Y. (2019). Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain. : Advances in Experimental Medicine and Biology (pp. 27-44). (Advances in Experimental Medicine and Biology; 巻数 1128). Springer New York LLC. https://doi.org/10.1007/978-981-13-3540-2_3

Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain. / Nakabeppu, Yusaku.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. p. 27-44 (Advances in Experimental Medicine and Biology; 巻 1128).

研究成果: 著書/レポートタイプへの貢献

Nakabeppu, Y 2019, Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain. : Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, 巻. 1128, Springer New York LLC, pp. 27-44. https://doi.org/10.1007/978-981-13-3540-2_3
Nakabeppu Y. Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain. : Advances in Experimental Medicine and Biology. Springer New York LLC. 2019. p. 27-44. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-981-13-3540-2_3
Nakabeppu, Yusaku. / Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain. Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. pp. 27-44 (Advances in Experimental Medicine and Biology).
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