Molecular structure of matrices solubilized with HCl from decellularized liver and the production of albumin from hepatocytes cultured on the matrices

Shintaro Nakamura, Souta Nishimura, Hiroyuki Ijima

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Solubilized liver-specific extracellular matrix (ECM) as a functional culture substratum was evaluated in this study. Briefly, the various types of solubilized ECMs were prepared from decellularized liver with HCl of various concentrations. The concentration of HCl affected the molecular structure of the solubilized ECMs. On the other hand, the level of albumin production from hepatocytes cultured on the solubilized ECMs films were higher than that of type I collagen film. However, the differences of cell adhesive tendency and albumin production of hepatocytes were could not be observed among various ECMs. Therefore, liver ECM composition is effective as a hepatocyte culture substratum.

本文言語英語
ページ(範囲)O-194-O-195
ジャーナルTransactions of Japanese Society for Medical and Biological Engineering
52
DOI
出版ステータス出版済み - 8月 17 2014

!!!All Science Journal Classification (ASJC) codes

  • 生体医工学

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