Molecular targeting therapy for renal cell carcinoma

Masatoshi Eto, Seiji Naito

研究成果: ジャーナルへの寄稿評論記事

25 引用 (Scopus)

抄録

Metastatic renal cell carcinoma (RCC) is currently one of the most treatment-resistant malignancies. However, significant advances in understanding the molecular mechanisms underlying RCC have led to the development of rationally designed therapies, which are now being tested clinically. To date, the vascular endothelial growth factor receptor (VEGFR) pathway has been the most promising target, and two agents (BAY 43-9006 and SU 11248) that inhibit not only VEGFR but also other receptors, including platelet-derived growth factor receptor (PDGFR), FMS-like tyrosine kinase 3 (FLT3), KIT, and Raf kinase, were recently approved by the FDA for advanced RCC. In addition, a phase III trial investigating the addition of VEGF inhibition to interferon alpha (IFN-α) in RCC is also now going on. Although the clinical activity of existing agents is to be further defined in ongoing trials, the exciting clinical response data with VEGF inhibition in RCC have demonstrated a key role in the treatment of this historically resistant malignancy.

元の言語英語
ページ(範囲)209-213
ページ数5
ジャーナルInternational Journal of Clinical Oncology
11
発行部数3
DOI
出版物ステータス出版済み - 6 1 2006

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Renal Cell Carcinoma
Vascular Endothelial Growth Factor Receptor
Vascular Endothelial Growth Factor A
raf Kinases
Therapeutics
Platelet-Derived Growth Factor Receptors
Interferon-alpha
Protein-Tyrosine Kinases
Neoplasms
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hematology
  • Oncology

これを引用

Molecular targeting therapy for renal cell carcinoma. / Eto, Masatoshi; Naito, Seiji.

:: International Journal of Clinical Oncology, 巻 11, 番号 3, 01.06.2006, p. 209-213.

研究成果: ジャーナルへの寄稿評論記事

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abstract = "Metastatic renal cell carcinoma (RCC) is currently one of the most treatment-resistant malignancies. However, significant advances in understanding the molecular mechanisms underlying RCC have led to the development of rationally designed therapies, which are now being tested clinically. To date, the vascular endothelial growth factor receptor (VEGFR) pathway has been the most promising target, and two agents (BAY 43-9006 and SU 11248) that inhibit not only VEGFR but also other receptors, including platelet-derived growth factor receptor (PDGFR), FMS-like tyrosine kinase 3 (FLT3), KIT, and Raf kinase, were recently approved by the FDA for advanced RCC. In addition, a phase III trial investigating the addition of VEGF inhibition to interferon alpha (IFN-α) in RCC is also now going on. Although the clinical activity of existing agents is to be further defined in ongoing trials, the exciting clinical response data with VEGF inhibition in RCC have demonstrated a key role in the treatment of this historically resistant malignancy.",
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