TY - JOUR
T1 - Molecularly imprinted polymer with a pseudo-template for thermo-responsive adsorption/desorption based on hydrogen bonding
AU - Kubo, Takuya
AU - Koterasawa, Katsuaki
AU - Naito, Toyohiro
AU - Otsuka, Koji
N1 - Funding Information:
This research was partly supported by the Grant-in Aid for Scientific Research (Nos. 25620111 and 24350039 ) from the Japan Society for the Promotion of Science and an Environment Research and Technology Development Fund ( 5-1552 ) from the Ministry of the Environment, Japan .
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/7/28
Y1 - 2015/7/28
N2 - Abstract We report a thermo-responsive molecularly imprinted polymer (MIP) for methotrexate, an anticancer drug. The bulk MIPs were prepared with divinylbenzene as a crosslinker, a variety of functional monomers, and folic acid as a pseudo-template molecule. As a result of simple batch adsorption for methotrexate or folic acid using the MIPs, the selectivity depended on the functional monomers because the functional groups of methotrexate or folic acid were slightly different in each other. After optimization of the preparation conditions, only acidic functional monomers including methacrylic acid (MAA) and sodium p-styrenesulfonate (SS) contributed to the selective adsorption for methotrexate. Furthermore, only the MAA-based MIP provided the thermal responsibility for the binding/release of methotrexate by the suppression of hydrogen bonding at higher temperature, whereas a strong ionic interaction was contributed among broad temperature range in the SS-based MIP. Adsorption isotherms also well supported the differences of the molecular recognition based on the binding constants at low and higher temperatures. Finally, we successfully demonstrated the drug-releasing ability by simple temperature changing with the MAA-based MIP.
AB - Abstract We report a thermo-responsive molecularly imprinted polymer (MIP) for methotrexate, an anticancer drug. The bulk MIPs were prepared with divinylbenzene as a crosslinker, a variety of functional monomers, and folic acid as a pseudo-template molecule. As a result of simple batch adsorption for methotrexate or folic acid using the MIPs, the selectivity depended on the functional monomers because the functional groups of methotrexate or folic acid were slightly different in each other. After optimization of the preparation conditions, only acidic functional monomers including methacrylic acid (MAA) and sodium p-styrenesulfonate (SS) contributed to the selective adsorption for methotrexate. Furthermore, only the MAA-based MIP provided the thermal responsibility for the binding/release of methotrexate by the suppression of hydrogen bonding at higher temperature, whereas a strong ionic interaction was contributed among broad temperature range in the SS-based MIP. Adsorption isotherms also well supported the differences of the molecular recognition based on the binding constants at low and higher temperatures. Finally, we successfully demonstrated the drug-releasing ability by simple temperature changing with the MAA-based MIP.
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U2 - 10.1016/j.micromeso.2015.07.006
DO - 10.1016/j.micromeso.2015.07.006
M3 - Article
AN - SCOPUS:84938068820
VL - 218
SP - 112
EP - 117
JO - Zeolites
JF - Zeolites
SN - 1387-1811
M1 - 7211
ER -