Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas

Michael Platten, Alexandra Kretz, Ulrike Naumann, Steffen Aulwurm, Kensuke Egashira, Stefan Isenmann, Michael Weller

研究成果: ジャーナルへの寄稿記事

143 引用 (Scopus)

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Macrophages are thought to represent a first line of defense in anti-tumor immunity. Despite infiltration by microglial cells, however, malignant gliomas are still highly aggressive tumors. We here identify monocyte chemoattractant protein-1 (MCP-1) as a critical chemoattractant for glioma-infiltrating microglial cells. MCP-1-transfected rat CNS-1 gliomas were massively infiltrated by microglial cells. Whereas MCP-1 did not promote the growth of CNS-1 cells in vitro, intracerebral CNS-1-transfected tumors grew more aggressively than control-transfected tumors. This provides the first functional evidence that MCP-1 recruits microglial cells to gliomas and promotes their growth in vivo. Microglial cells may support rather than suppress glioma growth.

元の言語英語
ページ(範囲)388-392
ページ数5
ジャーナルAnnals of Neurology
54
発行部数3
DOI
出版物ステータス出版済み - 9 1 2003

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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