Monolayer Properties of Hydrophobic α-Helical Peptides Having Various End Groups at the Air/Water Interface

Katsuhiko Fujita, Shunsaku Kimura, Yukio Imanishi, Elmar Rump, Helmut Ringsdorf

研究成果: Contribution to journalArticle査読

22 被引用数 (Scopus)

抄録

A hydrophobic peptide, Boc-(Ala-Aib)8-OMe (BA16M), and its end-modified derivatives were synthesized, and the pressure-area (π-A) isotherms of the peptides spread at the air/water interface were studied from the viewpoint of interhelix interactions. All π-A isotherms of the synthetic peptides showed an inflection and weak irregular bumping at a surface areas of about 240 and 230 Å2/molecule, respectively, indicating that the helix axis of the peptide is oriented parallel to the interface. A small mound was observed at around 300 Å2/molecule in the π-a isotherm of BA16M, which was ascribed to the phase transition from a liquid to a solid state. The monolayer of an equimolar mixture of the peptides having an opposite kind of charge in the end group underwent the phase transition in the π-A isotherm, which was not observed with one of the two peptides. The electrostatic interaction between the end groups should stabilize the molecular packing at the interface.

本文言語英語
ページ(範囲)2731-2735
ページ数5
ジャーナルLangmuir
10
8
DOI
出版ステータス出版済み - 8 1 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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