TY - JOUR
T1 - Mortality in Yusho patients exposed to polychlorinated biphenyls and polychlorinated dibenzofurans
T2 - a 50-year retrospective cohort study
AU - Onozuka, Daisuke
AU - Nakamura, Yuko
AU - Tsuji, Gaku
AU - Furue, Masutaka
N1 - Funding Information:
The authors express their sincere appreciation to Yuko Katsuno, Keiko Kajishima, Sachiyo Tadakuma, Mikiko Yamane, Yoshihito Kawakami, Naomi Nishizawa, and Kenichiro Miura, who greatly contributed to the management of the cohort data for the Yusho patients. The authors are also grateful to the staffs of the Ministry of Health, Labour and Welfare and prefectural and municipal government which contributed to the collection of follow-up data.
Funding Information:
This work was supported by the Ministry of Health, Labour and Welfare Research Grant Number H30-Shokuhin-Shitei-005. The funding sources had no role in the study design, data collection, data analysis, data interpretation, or preparation of the manuscript.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12
Y1 - 2020/12
N2 - Background: In 1968, the Yusho incident resulted in accidental exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related compounds in Japan. This study updated the risk of mortality in Yusho patients. Methods: We obtained updated cohort data for all Yusho patients for the period 1968–2017. We calculated standardized mortality ratios (SMRs) for all-cause and cause-specific mortality over a 50-year follow-up period compared with the general population in Japan. Results: A total of 1664 Yusho patients with 63,566 person-years of follow up were included in the analysis. Among males, excess mortality was observed for all cancers (SMR: 1.22, 95% confidence interval [CI]: 1.02 to 1.45) and lung cancer (SMR: 1.59, 95% CI: 1.12 to 2.19). Among females, increased mortality was observed for liver cancer (SMR: 2.05, 95% CI: 1.02 to 3.67). No significant increase was seen in non-cancer-related mortality compared with the general population. Conclusions: Carcinogenic risk in humans after exposure to PCBs and PCDFs remains higher among Yusho patients. Our findings suggest the importance of care engagement and optimum management to deal with the burden of Yusho disease.
AB - Background: In 1968, the Yusho incident resulted in accidental exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related compounds in Japan. This study updated the risk of mortality in Yusho patients. Methods: We obtained updated cohort data for all Yusho patients for the period 1968–2017. We calculated standardized mortality ratios (SMRs) for all-cause and cause-specific mortality over a 50-year follow-up period compared with the general population in Japan. Results: A total of 1664 Yusho patients with 63,566 person-years of follow up were included in the analysis. Among males, excess mortality was observed for all cancers (SMR: 1.22, 95% confidence interval [CI]: 1.02 to 1.45) and lung cancer (SMR: 1.59, 95% CI: 1.12 to 2.19). Among females, increased mortality was observed for liver cancer (SMR: 2.05, 95% CI: 1.02 to 3.67). No significant increase was seen in non-cancer-related mortality compared with the general population. Conclusions: Carcinogenic risk in humans after exposure to PCBs and PCDFs remains higher among Yusho patients. Our findings suggest the importance of care engagement and optimum management to deal with the burden of Yusho disease.
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U2 - 10.1186/s12940-020-00680-0
DO - 10.1186/s12940-020-00680-0
M3 - Article
C2 - 33228703
AN - SCOPUS:85096455461
SN - 1476-069X
VL - 19
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
IS - 1
M1 - 119
ER -
