Mouse D-amino-acid oxidase

Distribution and physiological substrates

Reiko Koga, Yurika Miyoshi, Hiroaki Sakaue, Kenji Hamase, Ryuichi Konno

研究成果: ジャーナルへの寄稿評論記事

6 引用 (Scopus)

抄録

D-Amino-acid oxidase (DAO) catalyzes the oxidative deamination of D-amino acids. DAO is present in a wide variety of organisms and has important roles. Here, we review the distribution and physiological substrates of mouse DAO. Mouse DAO is present in the kidney, brain, and spinal cord, like DAOs in other mammals. However, in contrast to other animals, it is not present in the mouse liver. Recently, DAO has been detected in the neutrophils, retina, and small intestine in mice. To determine the physiological substrates of mouse DAO, mutant mice lacking DAO activity are helpful. As DAO has wide substrate specificity and degrades various D-amino acids, many D-amino acids accumulate in the tissues and body fluids of the mutant mice. These amino acids are D-methionine, D-alanine, D-serine, D-leucine, D-proline, D-phenylalanine, D-tyrosine, and D-citrulline. Even in wild-type mice, administration of DAO inhibitors elevates D-serine levels in the plasma and brain. Among the above D-amino acids, the main physiological substrates of mouse DAO are D-alanine and D-serine. These two D-amino acids are most abundant in the tissues and body fluids of mice. D-Alanine derives from bacteria and produces bactericidal reactive oxygen species by the action of DAO. D-Serine is synthesized by serine racemase and is present especially in the central nervous system, where it serves as a neuromodulator. DAO is responsible for the metabolism of D-serine. Since DAO has been implicated in the etiology of neuropsychiatric diseases, mouse DAO has been used as a representative model. Recent reports, however, suggest that mouse DAO is different from human DAO with respect to important properties.

元の言語英語
記事番号82
ジャーナルFrontiers in Molecular Biosciences
4
発行部数DEC
DOI
出版物ステータス出版済み - 12 4 2017

Fingerprint

D-Amino-Acid Oxidase
Substrates
Serine
Amino Acids
Alanine
Body fluids
Body Fluids
Brain
Tissue
Citrulline
Deamination
Mammals

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

これを引用

Mouse D-amino-acid oxidase : Distribution and physiological substrates. / Koga, Reiko; Miyoshi, Yurika; Sakaue, Hiroaki; Hamase, Kenji; Konno, Ryuichi.

:: Frontiers in Molecular Biosciences, 巻 4, 番号 DEC, 82, 04.12.2017.

研究成果: ジャーナルへの寄稿評論記事

Koga, Reiko ; Miyoshi, Yurika ; Sakaue, Hiroaki ; Hamase, Kenji ; Konno, Ryuichi. / Mouse D-amino-acid oxidase : Distribution and physiological substrates. :: Frontiers in Molecular Biosciences. 2017 ; 巻 4, 番号 DEC.
@article{4623f59288d1452e8e201e8da27c860e,
title = "Mouse D-amino-acid oxidase: Distribution and physiological substrates",
abstract = "D-Amino-acid oxidase (DAO) catalyzes the oxidative deamination of D-amino acids. DAO is present in a wide variety of organisms and has important roles. Here, we review the distribution and physiological substrates of mouse DAO. Mouse DAO is present in the kidney, brain, and spinal cord, like DAOs in other mammals. However, in contrast to other animals, it is not present in the mouse liver. Recently, DAO has been detected in the neutrophils, retina, and small intestine in mice. To determine the physiological substrates of mouse DAO, mutant mice lacking DAO activity are helpful. As DAO has wide substrate specificity and degrades various D-amino acids, many D-amino acids accumulate in the tissues and body fluids of the mutant mice. These amino acids are D-methionine, D-alanine, D-serine, D-leucine, D-proline, D-phenylalanine, D-tyrosine, and D-citrulline. Even in wild-type mice, administration of DAO inhibitors elevates D-serine levels in the plasma and brain. Among the above D-amino acids, the main physiological substrates of mouse DAO are D-alanine and D-serine. These two D-amino acids are most abundant in the tissues and body fluids of mice. D-Alanine derives from bacteria and produces bactericidal reactive oxygen species by the action of DAO. D-Serine is synthesized by serine racemase and is present especially in the central nervous system, where it serves as a neuromodulator. DAO is responsible for the metabolism of D-serine. Since DAO has been implicated in the etiology of neuropsychiatric diseases, mouse DAO has been used as a representative model. Recent reports, however, suggest that mouse DAO is different from human DAO with respect to important properties.",
author = "Reiko Koga and Yurika Miyoshi and Hiroaki Sakaue and Kenji Hamase and Ryuichi Konno",
year = "2017",
month = "12",
day = "4",
doi = "10.3389/fmolb.2017.00082",
language = "English",
volume = "4",
journal = "Frontiers in Molecular Biosciences",
issn = "2296-889X",
publisher = "Frontiers Media S. A.",
number = "DEC",

}

TY - JOUR

T1 - Mouse D-amino-acid oxidase

T2 - Distribution and physiological substrates

AU - Koga, Reiko

AU - Miyoshi, Yurika

AU - Sakaue, Hiroaki

AU - Hamase, Kenji

AU - Konno, Ryuichi

PY - 2017/12/4

Y1 - 2017/12/4

N2 - D-Amino-acid oxidase (DAO) catalyzes the oxidative deamination of D-amino acids. DAO is present in a wide variety of organisms and has important roles. Here, we review the distribution and physiological substrates of mouse DAO. Mouse DAO is present in the kidney, brain, and spinal cord, like DAOs in other mammals. However, in contrast to other animals, it is not present in the mouse liver. Recently, DAO has been detected in the neutrophils, retina, and small intestine in mice. To determine the physiological substrates of mouse DAO, mutant mice lacking DAO activity are helpful. As DAO has wide substrate specificity and degrades various D-amino acids, many D-amino acids accumulate in the tissues and body fluids of the mutant mice. These amino acids are D-methionine, D-alanine, D-serine, D-leucine, D-proline, D-phenylalanine, D-tyrosine, and D-citrulline. Even in wild-type mice, administration of DAO inhibitors elevates D-serine levels in the plasma and brain. Among the above D-amino acids, the main physiological substrates of mouse DAO are D-alanine and D-serine. These two D-amino acids are most abundant in the tissues and body fluids of mice. D-Alanine derives from bacteria and produces bactericidal reactive oxygen species by the action of DAO. D-Serine is synthesized by serine racemase and is present especially in the central nervous system, where it serves as a neuromodulator. DAO is responsible for the metabolism of D-serine. Since DAO has been implicated in the etiology of neuropsychiatric diseases, mouse DAO has been used as a representative model. Recent reports, however, suggest that mouse DAO is different from human DAO with respect to important properties.

AB - D-Amino-acid oxidase (DAO) catalyzes the oxidative deamination of D-amino acids. DAO is present in a wide variety of organisms and has important roles. Here, we review the distribution and physiological substrates of mouse DAO. Mouse DAO is present in the kidney, brain, and spinal cord, like DAOs in other mammals. However, in contrast to other animals, it is not present in the mouse liver. Recently, DAO has been detected in the neutrophils, retina, and small intestine in mice. To determine the physiological substrates of mouse DAO, mutant mice lacking DAO activity are helpful. As DAO has wide substrate specificity and degrades various D-amino acids, many D-amino acids accumulate in the tissues and body fluids of the mutant mice. These amino acids are D-methionine, D-alanine, D-serine, D-leucine, D-proline, D-phenylalanine, D-tyrosine, and D-citrulline. Even in wild-type mice, administration of DAO inhibitors elevates D-serine levels in the plasma and brain. Among the above D-amino acids, the main physiological substrates of mouse DAO are D-alanine and D-serine. These two D-amino acids are most abundant in the tissues and body fluids of mice. D-Alanine derives from bacteria and produces bactericidal reactive oxygen species by the action of DAO. D-Serine is synthesized by serine racemase and is present especially in the central nervous system, where it serves as a neuromodulator. DAO is responsible for the metabolism of D-serine. Since DAO has been implicated in the etiology of neuropsychiatric diseases, mouse DAO has been used as a representative model. Recent reports, however, suggest that mouse DAO is different from human DAO with respect to important properties.

UR - http://www.scopus.com/inward/record.url?scp=85039802743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039802743&partnerID=8YFLogxK

U2 - 10.3389/fmolb.2017.00082

DO - 10.3389/fmolb.2017.00082

M3 - Review article

VL - 4

JO - Frontiers in Molecular Biosciences

JF - Frontiers in Molecular Biosciences

SN - 2296-889X

IS - DEC

M1 - 82

ER -